Abstract | AIM: METHODS: A total of 50 Chinese SH patients and 22 healthy volunteers were recruited. SH patients received TRT (L-T4, 25 and 50 mcg/d for patients with TSH≤10.0 mIU/L and TSH>10.0 mIU/L, respectively) for 3 months. Serum levels of major eicosanoids and cPLA2 were analyzed using LC-MS and clinical biochemical assays. RESULTS: The serum levels of cPLA2, eicosanoids (8-isoPGF2a, 11-dehydroTXB2 and 12-HETE) and 11-dehydroTXB2/6-Keto-PGF1a were significantly elevated in SH patients. The serum TSH levels were significantly correlated with the levels of cPLA2 (r=+0.65), 11-dehydroTXB2 (r=+0.32) and 11-dehydroTXB2/6-Keto-PGF1a (r=+0.37). After 3-month TRT, the serum levels of TSH, cPLA2 and the above-mentioned eicosanoids in SH patients were significantly decreased. CONCLUSION: The metabolism of eicosanoids is significantly altered in Chinese SH patients, and TRT can ameliorate the abnormalities of serum eicosanoid levels.
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Authors | Yan Zhang, Bing-Chang Zhang, Jin Xu, Meng Zhao, Zhe Wang, Yong-Feng Song, Hai-Qing Zhang, Ling Gao, Qun-Ye Zhang, Jia-Jun Zhao |
Journal | Acta pharmacologica Sinica
(Acta Pharmacol Sin)
Vol. 37
Issue 5
Pg. 656-63
(May 2016)
ISSN: 1745-7254 [Electronic] United States |
PMID | 26997566
(Publication Type: Journal Article)
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Chemical References |
- Eicosanoids
- Phospholipases A2
- Thyroxine
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Topics |
- Asian People
- Eicosanoids
(blood)
- Female
- Hormone Replacement Therapy
- Humans
- Hypothyroidism
(blood, drug therapy, ethnology)
- Male
- Phospholipases A2
(blood)
- Thyroxine
(therapeutic use)
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