Abstract | OBJECTIVES: MATERIALS AND METHODS: Therefore, we investigated the cell number and biologic activity by cell migration and colony-forming ability of EPC. Cells were isolated from the peripheral venous blood of 79 patients who suffer HNSCC in different stages of disease. Thirty-three healthy individuals served as the control group. RESULTS: Significantly increased biological activities were reflected by expression of the migration rate (1027 ± 1510) in comparison to the control group (632 ± 269) and the clonal potency measured by colony-forming unit (CFU) ( tumor patients (19.7 ± 12.3) vs. control group (10.84 ± 4.8)). To determine whether or not EPC number can be used as a valid prognostic marker for clinical outcome of tumor patients, we furthermore compared a "high EPC-number-subgroup" (HI) with a "low EPC-number-subgroup" (LO) in a Kaplan-Meier survival curve. The HI-subgroup shows herein clearly a worse outcome. CONCLUSIONS: Our findings indicate a possible pathway for EPC to play a critical role in the vasculogenesis and consequently in the progression of HNSCC. CLINICAL RELEVANCE: Our findings could serve as possible predictors for the neovascularisation potential in HNSCC tumor patients.
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Authors | Thomas Ziebart, Sebastian Blatt, Christian Günther, Nadine Völxen, Andreas Pabst, Keyvan Sagheb, Sebastian Kühl, Thomas Lambrecht |
Journal | Clinical oral investigations
(Clin Oral Investig)
Vol. 20
Issue 8
Pg. 2293-2300
(Nov 2016)
ISSN: 1436-3771 [Electronic] Germany |
PMID | 26993659
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Aged
- Biomarkers, Tumor
- Carcinogenesis
(pathology)
- Carcinoma, Squamous Cell
(pathology)
- Case-Control Studies
- Cell Movement
- Cell Transformation, Neoplastic
(pathology)
- Disease Progression
- Endothelial Progenitor Cells
(pathology)
- Female
- Head and Neck Neoplasms
(pathology)
- Humans
- Lymphatic Metastasis
(pathology)
- Male
- Middle Aged
- Neoplasm Staging
- Neovascularization, Pathologic
(pathology)
- Prognosis
- Stem Cells
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