[Filtration of active fractions with function of expelling water retention with drastic purgative from Kansui Radix stir-baked with vinegar].

Abstract

To study the function of expelling water retention with drastic purgative of different polarities of Kansui Radix stir-baked with vinegar on the cancerous ascites model rats, the furosemide was taken as positive control drug, and the cancerous ascites model rats were respectively orally administered with different polarities of Kansui Radix stir-baked with vinegar for 7 d. The amount of urine and ascites, the level of urinary sodium, potassium, chloride ion and pH, and the content of PRL1, AII, ALD in serum were investigated. Compared with model groups, ethyl acetate extract group showed a decreasing trend in ascites; the amount of urine of showed a significant increase (P < 0.05); the level of urinary sodium, potassium, chloride ion (P < 0.05, P < 0.01), pH (P < 0.05), and the content of PRL1, AII, ALD in serum all showed a significant decrease (P < 0.01). The effects of petroleum ether extract and n-butanol extract were weaker than that of ethyl acetate extract. The water exact was the weakest. The results showed that ethyl acetate extract is the active part of Kansui Radix stir-baked with vinegar on the function of expelling water retention with drastic purgative on the cancerous ascites model rats, alleviating the water-electrolyte disorder and body fluid acid-base imbalance, regulating the renin angiotensin aldosterone system.

• Authors: Liang-liang Cao, Wen-xiao Wang, Qiao Zhang, Li Zhang, An-wei Ding, Zhi-hua Dou
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 40 Issue 18 Pg. 3655-9 (Sep 2015) ISSN: 1001-5302 [Print] China
• PMID: 26983216 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cathartics
• Drugs, Chinese Herbal
• Water
• Sodium
• Potassium

Topics

• Animals
• Ascites (drug therapy, metabolism)
• Cathartics (administration & dosage, chemistry, isolation & purification)
• Chemistry, Pharmaceutical
• Drugs, Chinese Herbal (administration & dosage, chemistry, isolation & purification)
• Euphorbia (chemistry)
• Humans
• Male
• Plant Roots (chemistry)
• Potassium (urine)
• Rats
• Rats, Sprague-Dawley
• Sodium (urine)
• Water (metabolism)