Abstract | BACKGROUND: Chronic ocular allergic diseases such as vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (AKC) are accompanied by serious comorbidities; however, the underlying pathogenesis remains obscure. Furthermore, diagnosing conjunctival lesions in patients with atopic dermatitis and estimating the severity in AKC are important for the treatment of ocular allergic diseases. OBJECTIVE: METHODS: RESULTS: Tears from patients with ocular allergic disease showed significantly high periostin levels than did tears from allergic patients without conjunctivitis and from patients with AKC, VKC, and SAC in descending order. Tear periostin was associated with serious comorbidities such as large papilla formation and corneal damage in AKC, although both tear IL-13 and serum periostin had little to no such abilities. Furthermore, after topical tacrolimus treatment, tear periostin tended to decrease in most patients with AKC along with their clinical improvement. CONCLUSIONS:
Periostin produced in conjunctival tissues stimulated by IL-13 may contribute to the pathogenesis of ocular allergic diseases. Furthermore, tear periostin can be potentially applied as a biomarker to diagnose conjunctivitis in allergic patients and to evaluate disease severity as well as the efficacy of treatments in AKC.
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Authors | Hiroshi Fujishima, Naoko Okada, Kenji Matsumoto, Kazumi Fukagawa, Ayako Igarashi, Akio Matsuda, Junya Ono, Shoichiro Ohta, Hideki Mukai, Mamoru Yoshikawa, Kenji Izuhara |
Journal | The Journal of allergy and clinical immunology
(J Allergy Clin Immunol)
Vol. 138
Issue 2
Pg. 459-467.e2
(08 2016)
ISSN: 1097-6825 [Electronic] United States |
PMID | 26964692
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2016 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- Cell Adhesion Molecules
- Interleukin-13
- POSTN protein, human
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Topics |
- Biomarkers
- Case-Control Studies
- Cell Adhesion Molecules
(metabolism)
- Chronic Disease
- Conjunctivitis, Allergic
(diagnosis, metabolism)
- Disease Management
- Enzyme-Linked Immunosorbent Assay
- Epithelial Cells
(metabolism)
- Eye Diseases
(diagnosis, metabolism)
- Female
- Fibroblasts
(metabolism)
- Humans
- Hypersensitivity
(diagnosis, metabolism)
- Interleukin-13
(blood, metabolism)
- Male
- Tears
(metabolism)
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