Hypofractionated radiotherapy for localized prostate cancer using three-dimensional conformal radiotherapy technique: 3 years toxicity analysis.

Abstract

BACKGROUND:

Hypofractionated radiotherapy in the radical treatment of localized prostate cancer has potential biological advantages relative to conventional fractionation. We report prospectively collected toxicity data from a cohort of patients treated with a 3D conformal technique (3DCRT).

MATERIALS AND METHODS:

90 patients receiving curative intent hypofractionated radiotherapy with 57Gy in 19 daily fractions over 3.8 weeks were evaluated prospectively for the development of radiation related toxicity over a 3 year period.

RESULTS:

All patients completed treatment. Maximal acute toxicity experienced was 58.6, 10 and 1.1% for grade 1, 2 and 3 genitourinary (GU) toxicity respectively and 75.6, 9 and 0% for gastrointestinal (GI) toxicity. For late toxicity the three year actuarial rates of grade 1, 2 and 3 GU and GI toxicity respectively were 47.3, 2.4 and 0%; and 40, 9.3 and 4.7%. There were no grade 4 or worse acute or late toxicities. 97.6% of evaluable patients remained free of biochemical failure 36 months post radiotherapy.

CONCLUSIONS:

A 57Gy in 19 daily fraction radiotherapy schedule using 3D conformal radiotherapy for the definitive treatment of localized prostate cancer has acceptable early and late toxicity.

• Authors: R White, D Woolf, S Li, R Alonzi, P Osler, P Hoskin, R Hughes
• Journal: Indian journal of cancer (Indian J Cancer) 2015 Oct-Dec Vol. 52 Issue 4 Pg. 654-7 ISSN: 1998-4774 [Electronic] India
• PMID: 26960508 (Publication Type: Journal Article)

Topics

• Aged
• Aged, 80 and over
• Dose Fractionation, Radiation
• Humans
• Male
• Middle Aged
• Prostatic Neoplasms (diagnostic imaging, radiotherapy)
• Radiotherapy, Conformal (methods)