Abstract | RATIONALE:
Bronchiectasis is a condition characterised by dilated and thick-walled bronchi. The presence of Pseudomonas aeruginosa in bronchiectasis is associated with a higher hospitalisation frequency and a reduced quality of life, requiring frequent and adequate treatment with antibiotics. OBJECTIVES: METHODS: Eight participants in the study were trained in handling the device and inhaling correctly. During drug administration the inspiratory flow curve was recorded. Local tolerability was assessed by spirometry and recording adverse events. Serum samples were collected before, and 15, 30, 45, 60, 75, 90, 105, 120 min; 4, 8 and 12 h after inhalation. RESULTS AND DISCUSSION: Dry powder tobramycin base was well tolerated and mild tobramycin-related cough was reported only once. A good drug dose-serum concentration correlation was obtained. Relatively small inhaled volumes were computed from the recorded flow curves, resulting in presumably substantial deposition in the central airways-i.e., at the site of infection. CONCLUSIONS:
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Authors | Marcel Hoppentocht, Onno W Akkerman, Paul Hagedoorn, Jan-Willem C Alffenaar, Tjip S van der Werf, Huib A M Kerstjens, Henderik W Frijlink, Anne H de Boer |
Journal | PloS one
(PLoS One)
Vol. 11
Issue 3
Pg. e0149768
( 2016)
ISSN: 1932-6203 [Electronic] United States |
PMID | 26959239
(Publication Type: Clinical Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Administration, Inhalation
- Adult
- Aged
- Bronchiectasis
(complications, drug therapy, physiopathology)
- Cystic Fibrosis
(complications, drug therapy, physiopathology)
- Dose-Response Relationship, Drug
- Dry Powder Inhalers
- Female
- Forced Expiratory Volume
- Humans
- Male
- Middle Aged
- Powders
- Tobramycin
(administration & dosage, adverse effects, blood, pharmacokinetics)
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