Prophylactic use of pregabalin for prevention of succinylcholine-induced fasciculation and myalgia: a randomized, double-blinded, placebo-controlled study.

Abstract

BACKGROUND:

Succinylcholine is commonly used to achieve profound neuromuscular blockade of rapid onset and short duration.

OBJECTIVE:

The present study compared the efficacy of pregabalin for prevention of succinylcholine-induced fasciculation and myalgia.

DESIGN:

Prospective, randomized, placebo controlled, double blinded study.

MATERIALS AND METHODS:

Patients of both genders undergoing elective spine surgery were randomly assigned to two groups. Patients in Group P (pregabalin group) received 150mg of pregabalin orally 1h prior to induction of anesthesia with sips of water and patients in Group C (control group) received placebo. Anesthesia was induced with fentanyl 1.5mcg/kg, propofol 1.5-2.0mg/kg followed by succinylcholine 1.5mg/kg. The intensity of fasciculations was assessed by an observer blinded to the group allotment of the patient on a 4-point scale. A blinded observer recorded postoperative myalgia grade after 24h of surgery. Patients were provided patient-controlled analgesia with fentanyl for postoperative pain relief.

RESULTS:

Demographic data of both groups were comparable (p>0.05). The incidence of muscle fasciculation's was not significant between two groups (p=0.707), while more patients in group C had moderate to severe fasciculation's compared to group P (p=0.028). The incidence and severity of myalgia were significantly lower in group P (p<0.05).

CONCLUSION:

Pregabalin 150mg prevents succinylcholine-induced fasciculations and myalgia and also decreases the fentanyl consumption in elective sine surgery.

• Authors: Vinit K Srivastava, Sanjay Agrawal, Vikrant K Nimbhorkar, Abhishek Mishra, Sunil Sharma, Prasanta K Panda
• Journal: Brazilian journal of anesthesiology (Elsevier) (Braz J Anesthesiol) 2016 Mar-Apr Vol. 66 Issue 2 Pg. 165-70 ISSN: 2352-2291 [Electronic] Brazil
• PMID: 26952225 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2014 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.

Chemical References

• Pregabalin
• Succinylcholine
• Fentanyl
• Propofol

Topics

• Adult
• Analgesia, Patient-Controlled (methods)
• Double-Blind Method
• Elective Surgical Procedures (methods)
• Fasciculation (chemically induced, epidemiology, prevention & control)
• Female
• Fentanyl (administration & dosage)
• Humans
• Incidence
• Male
• Middle Aged
• Myalgia (chemically induced, epidemiology, prevention & control)
• Pregabalin (therapeutic use)
• Propofol (administration & dosage)
• Prospective Studies
• Spine (surgery)
• Succinylcholine (administration & dosage, adverse effects)
• Young Adult