Pediatric Cardiac Intensive Care Society 2014 Consensus Statement: Pharmacotherapies in Cardiac Critical Care Pulmonary Hypertension.

Abstract

OBJECTIVE:

To review the pharmacologic treatment options for pulmonary arterial hypertension in the cardiac intensive care setting and summarize the most-recent literature supporting these therapies.

DATA SOURCES AND STUDY SELECTION:

Literature search for prospective studies, retrospective analyses, and case reports evaluating the safety and efficacy of pulmonary arterial hypertension therapies.

DATA EXTRACTION:

Mechanisms of action and pharmacokinetics, treatment recommendations, safety considerations, and outcomes for specific medical therapies.

DATA SYNTHESIS:

Specific targeted therapies developed for the treatment of adult patients with pulmonary arterial hypertension have been applied for the benefit of children with pulmonary arterial hypertension. With the exception of inhaled nitric oxide, there are no pulmonary arterial hypertension medications approved for children in the United States by the Food and Drug Administration. Unfortunately, data on treatment strategies in children with pulmonary arterial hypertension are limited by the small number of randomized controlled clinical trials evaluating the safety and efficacy of specific treatments. The treatment options for pulmonary arterial hypertension in children focus on endothelial-based pathways. Calcium channel blockers are recommended for use in a very small, select group of children who are responsive to vasoreactivity testing at cardiac catheterization. Phosphodiesterase type 5 inhibitor therapy is the most-commonly recommended oral treatment option in children with pulmonary arterial hypertension. Prostacyclins provide adjunctive therapy for the treatment of pulmonary arterial hypertension as infusions (IV and subcutaneous) and inhalation agents. Inhaled nitric oxide is the first-line vasodilator therapy in persistent pulmonary hypertension of the newborn and is commonly used in the treatment of pulmonary arterial hypertension in the ICU. Endothelin receptor antagonists have been shown to improve exercise tolerance and survival in adult patients with pulmonary arterial hypertension. Soluble guanylate cyclase stimulators are the first drug class to be Food and Drug Administration approved for the treatment of chronic thromboembolic pulmonary hypertension.

CONCLUSIONS:

Literature and data supporting the safe and effective use of pulmonary arterial hypertension therapies in children in the cardiac intensive care are limited. Extrapolation of adult data has afforded safe medical treatment of pulmonary hypertension in children. Large multicenter trials are needed in the search for safe and effective therapy of pulmonary hypertension in children.

• Authors: John S Kim, Julia McSweeney, Joanne Lee, Dunbar Ivy
• Journal: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies (Pediatr Crit Care Med) Vol. 17 Issue 3 Suppl 1 Pg. S89-100 (Mar 2016) ISSN: 1529-7535 [Print] United States
• PMID: 26945333 (Publication Type: Consensus Development Conference, Journal Article, Practice Guideline, Review)

Chemical References

• Calcium Channel Blockers
• Cardiovascular Agents
• Endothelin Receptor Antagonists
• Vasodilator Agents
• Nitrous Oxide

Topics

• Adult
• Calcium Channel Blockers (administration & dosage, adverse effects)
• Cardiovascular Agents (therapeutic use)
• Child
• Coronary Care Units
• Critical Care (standards)
• Endothelin Receptor Antagonists (administration & dosage, adverse effects)
• Heart Defects, Congenital (complications)
• Heart Failure (complications)
• Humans
• Hypertension, Pulmonary (complications, drug therapy)
• Intensive Care Units, Pediatric
• Nitrous Oxide (administration & dosage, adverse effects)
• Vasodilator Agents (administration & dosage, adverse effects)