Although we previously demonstrated the contribution of the DP1receptor in
nasal obstruction using animals sensitized with
ovalbumin in the presence of adjuvant, the contribution of the DP1receptor in
sneezing is unclear. Here, we developed a mouse model of Japanese cedar (JC:Cryptomeria japonica)
pollinosis to evaluate the symptoms of
sneezing. To achieve this, we used JC pollen
crude extract in the absence of adjuvant to sensitize mice to develop a model closer to the pathophysiology of human JC
pollinosis. The immunologic and pharmacologic features of this model are highly similar to those observed in JC
pollinosis in humans. Using this model, we found that DP1receptor antagonists suppressed JC pollen extract-induced
sneezing and that a DP1receptor agonist induced
sneezing. Moreover, JC pollen extract-induced
sneezing was diminished in DP1receptor knockout mice. In conclusion, we developed a novel mouse model of
allergic rhinitis that closely mimics human JC
pollinosis. A strong contribution of DP1receptor signaling to
sneezing was demonstrated using this model, suggesting that DP1receptor antagonists could suppress
sneezing and
nasal obstruction, and therefore these agents could be a new therapeutic option for
allergic rhinitis.