The clinical value of exhaled nitric oxide in patients with lung cancer.

Abstract

INTRODUCTION AND OBJECTIVES:

To investigate the clinical value of fractional exhaled nitric oxide (FeNO) in lung cancer patients.

METHODS:

A total of 172 healthy control subjects and 164 patients with histopathologically confirmed lung cancer were enrolled in this study. The FeNO measurements and pulmonary function tests were conducted in the Chinese PLA General Hospital. The recorded data included FeNO, the forced expiratory volume in one second (FEV1 ), the forced vital capacity (FVC), FEV1 /FVC, the FEV1 (% predicted), the demographic characteristics, the presence of complications and the smoking status.

RESULTS:

The patients with lung cancer had a significantly higher level of eNO than the healthy control subjects (33.85 ± 15.63 ppb, n = 163; 16.83 ± 4.17 ppb, n = 172; P < 0.01). The areas under receiver operating characteristic curves for eNO predicting airway inflammation in lung cancer subjects and healthy control subjects was 0.932 (95% confidence interval: 0.904-0.961). In the lung cancer group, the eNO levels in the squamous cell carcinoma, adenocarcinoma, small-cell lung cancer and lung carcinoid tumor groups were significantly different (P < 0.01). Lung cancer patients with a predicted FEV1 % value <80% had a higher level of eNO than the patients with a predicted FEV1 % value ≥80%.

CONCLUSIONS:

The eNO levels in patients with lung cancer were higher than the normal level, especially in the patients with squamous cell carcinoma and small-cell lung cancer. The differences in eNO among the lung cancer subtypes were statistically significant. Measuring eNO will be helpful in diagnosing airway inflammation in lung cancer and in the classification of lung cancer.

• Authors: Peng-Fei Liu, Da-Hui Zhao, Yan Qi, Jian-Guo Wang, Ming Zhao, Kun Xiao, Li-Xin Xie
• Journal: The clinical respiratory journal (Clin Respir J) Vol. 12 Issue 1 Pg. 23-30 (Jan 2018) ISSN: 1752-699X [Electronic] England
• PMID: 26934059 (Publication Type: Comparative Study, Journal Article)
• Copyright: © 2016 The Authors. The Clinical Respiratory Journal Published by John Wiley & Sons Ltd.

Chemical References

• Biomarkers, Tumor
• Nitric Oxide

Topics

• Biomarkers, Tumor (analysis)
• Breath Tests (methods)
• Exhalation
• Female
• Forced Expiratory Volume (physiology)
• Humans
• Lung Neoplasms (diagnosis, metabolism, physiopathology)
• Male
• Middle Aged
• Neoplasm Staging
• Nitric Oxide (analysis)
• Prognosis
• Retrospective Studies
• Severity of Illness Index