Plasma NT-proBNP is independently associated with albuminuria in type 2 diabetes.

Abstract

OBJECTIVE:

The aim of this study is to investigate the relationship between plasma NH2-terminal pro-brain natriuretic peptide (NT-proBNP) levels and diabetic nephropathy in type 2 diabetic patients.

METHODS:

The records of 983 patients with type 2 diabetes hospitalized in the Endocrinology and Metabolism Department of Peking University People's Hospital between January 2009 and December 2012 were reviewed. Based on their urinary albumin-to-creatinine ratio (UACR), the subjects were divided into three groups, those with normal, micro- and macro-albuminuria. Clinical manifestations and biochemical parameters, including plasma NT-proBNP concentrations, were compared between the three groups. The association between plasma NT-proBNP levels and stages of diabetic nephropathy was also evaluated by ordinal and stepwise linear regression analyses.

RESULTS:

The median plasma NT-proBNP concentration in the 983 patients with type 2 diabetes was 60.3 pg/ml, which is within the normal range of healthy subjects. One-way ANOVA analysis showed significant differences in plasma NT-proBNP concentrations among the three groups (p=0.000). Ordinal logistic regression analysis showed that plasma NT-proBNP concentration was an independent risk factor for advanced diabetic nephropathy (odds ratio=1.87,95% CI 1.52-2.29, p=0.000). Plasma NT-proBNP concentration was highly correlated with UACR (r=0.421, p=0.000) and had an independently positive association with UACR by stepwise linear regression analysis (p=0.000).

CONCLUSION:

Plasma NT-proBNP levels correlated with the degree of diabetic nephropathy in patients with type 2 diabetes.

• Authors: Lingli Zhou, Xiaoling Cai, Minghui Li, Xueyao Han, Linong Ji
• Journal: Journal of diabetes and its complications (J Diabetes Complications) 2016 May-Jun Vol. 30 Issue 4 Pg. 669-74 ISSN: 1873-460X [Electronic] United States
• PMID: 26922580 (Publication Type: Journal Article)
• Copyright: Copyright © 2016 Elsevier Inc. All rights reserved.

Chemical References

• Glycated Hemoglobin A
• Peptide Fragments
• hemoglobin A1c protein, human
• pro-brain natriuretic peptide (1-76)
• Natriuretic Peptide, Brain

Topics

• Albuminuria (etiology)
• China (epidemiology)
• Cohort Studies
• Cross-Sectional Studies
• Diabetes Mellitus, Type 2 (blood, complications, urine)
• Diabetic Angiopathies (complications, epidemiology)
• Diabetic Nephropathies (complications, physiopathology)
• Diabetic Retinopathy (complications, epidemiology)
• Disease Progression
• Female
• Glycated Hemoglobin (analysis)
• Hospitals, University
• Humans
• Hypertension (complications, epidemiology)
• Male
• Middle Aged
• Natriuretic Peptide, Brain (blood)
• Peptide Fragments (blood)
• Prevalence
• Renal Insufficiency, Chronic (complications, physiopathology)
• Retrospective Studies
• Risk Factors
• Severity of Illness Index