Abstract | BACKGROUND: The Amazon is the largest rainforest in the world and is home to a rich biodiversity of medicinal plants. Several of these plants are used by the local population for the treatment of diseases, many of those with probable anti-inflammatory effect. The aim of the present investigation was to evaluate the in vitro antioxidant and anti- peroxidases potential of the ethanol extracts of five plants from the Brazilian Amazon (Byrsonima japurensis, Calycophyllum spruceanum, Maytenus guyanensis, Passiflora nitida and Ptychopetalum olacoides). METHODS: RESULTS: The stem bark extracts of C. spruceanum and M. guyanensis provided the highest free radical scavenging activities. C. spruceanum exhibited IC50 = 7.5 ± 0.9, 5.0 ± 0.1, 18.2 ± 3.0 and 92.4 ± 24.8 μg/mL for DPPH(•), ABTS(+•), O2 (-•) and (1)O2 assays, respectively. P. olacoides and C. spruceanum extracts also inhibited free radicals formation in the cell-based assay. At a concentration of 100 μg/mL, the extracts of C. spruceanum, B. japurensis inhibited horseradish peroxidase by 62 and 50 %, respectively. C. spruceanum, M. guyanensis, B. japurensis also inhibited myeloperoxidase in 72, 67 and 56 %, respectively. CONCLUSIONS:
|
Authors | Fabiano S de Vargas, Patricia D O Almeida, Ana Paula A de Boleti, Maria M Pereira, Tatiane P de Souza, Marne C de Vasconcellos, Cecilia Veronica Nunez, Adrian M Pohlit, Emerson S Lima |
Journal | BMC complementary and alternative medicine
(BMC Complement Altern Med)
Vol. 16
Pg. 83
(Feb 27 2016)
ISSN: 1472-6882 [Electronic] England |
PMID | 26921197
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Anti-Inflammatory Agents
- Antioxidants
- Plant Extracts
- Polyphenols
- Peroxidases
- Peroxidase
|
Topics |
- Animals
- Anti-Inflammatory Agents
(pharmacology)
- Antioxidants
(pharmacology)
- Brazil
- Humans
- Malpighiaceae
(chemistry)
- Maytenus
(chemistry)
- Medicine, Traditional
- Mice
- NIH 3T3 Cells
- Olacaceae
(chemistry)
- Passiflora
(chemistry)
- Peroxidase
- Peroxidases
(antagonists & inhibitors)
- Phytotherapy
- Plant Extracts
(pharmacology)
- Plants, Medicinal
(chemistry)
- Polyphenols
(analysis, pharmacology)
|