d-Allulose supplementation normalized the body weight and fat-pad mass in diet-induced obese mice via the regulation of lipid metabolism under isocaloric fed condition.

Abstract

SCOPE:

A number of findings suggest that zero-calorie d-allulose, also known as d-psicose, has beneficial effects on obesity-related metabolic disturbances. However, it is unclear whether d-allulose can normalize the metabolic status of diet-induced obesity without having an impact on the energy density. We investigated whether 5% d-allulose supplementation in a high fat diet(HFD) could normalize body fat in a diet-induced obesity animal model under isocaloric pair-fed conditions.

METHODS AND RESULTS:

Mice were fed an HFD with or without various sugar substitutes (d-glucose, d-fructose, erytritol, or d-allulose, n = 10 per group) for 16 wk. Body weight and fat-pad mass in the d-allulose group were dramatically lowered to that of the normal group with a simultaneous decrease in plasma leptin and resistin concentrations. d-allulose lowered plasma and hepatic lipids while elevating fecal lipids with a decrease in mRNA expression of CD36, ApoB48, FATP4, in the small intestine in mice. In the liver, activities of both fatty acid synthase and β-oxidation were downregulated by d-allulose to that of the normal group; however, in WAT, fatty acid synthase was decreased while β-oxidation activity was enhanced.

CONCLUSION:

Taken together, our findings suggest that 5% dietary d-allulose led to the normalization of the metabolic status of diet-induced obesity by altering lipid-regulating enzyme activities and their gene-expression level along with fecal lipids.

• Authors: Youngji Han, Hye Jin Han, Ae-Hyang Kim, Ji-Young Choi, Su-Jung Cho, Yong Bok Park, Un Ju Jung, Myung-Sook Choi
• Journal: Molecular nutrition & food research (Mol Nutr Food Res) Vol. 60 Issue 7 Pg. 1695-706 (07 2016) ISSN: 1613-4133 [Electronic] Germany
• PMID: 26920079 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Apolipoprotein B-48
• Blood Glucose
• CD36 Antigens
• Fatty Acid Transport Proteins
• Leptin
• Resistin
• Slc27a4 protein, mouse
• Sweetening Agents
• psicose
• Fructose
• Glucose

Topics

• Adiposity (drug effects)
• Animals
• Apolipoprotein B-48 (genetics, metabolism)
• Blood Glucose (metabolism)
• Body Weight (drug effects)
• CD36 Antigens (genetics, metabolism)
• Diet, High-Fat
• Dietary Supplements
• Fatty Acid Transport Proteins (genetics, metabolism)
• Fructose (administration & dosage)
• Gene Expression Regulation
• Glucose (administration & dosage)
• Leptin (blood)
• Lipid Metabolism (drug effects)
• Liver (drug effects, metabolism)
• Male
• Mice
• Mice, Inbred C57BL
• Mice, Obese
• Obesity (drug therapy, etiology)
• Resistin (blood)
• Sweetening Agents (administration & dosage)