Biomarker evaluation as a potential cause of gender differences in obesity paradox among patients with STEMI.

Abstract

BACKGROUND:

Obesity with its worldwide growing prevalence is an established cardiovascular risk factor with increased morbidity and mortality. However, the phenomenon, that mild to moderate obesity seems to represent a protective effect on diseases has been termed the "obesity paradox".

METHODS:

We retrospectively assessed 529 patients (72.6% male, mean age 59.7±12.7years) admitted with ST-elevation myocardial infarction (STEMI). The female and male study populations were separated into four body mass index (BMI) groups: ≤24.9kg/m(2), 25.0-29.9kg/m(2), 30.0-34.9kg/m(2) and ≥35.0kg/m(2). Blood samples of high-density lipoprotein cholesterol (HDL-c) and low-density lipoprotein cholesterol (LDL-c) were analyzed.

RESULTS:

With increasing BMI group the rate of major adverse cardiac events (MACE) decreased in all patients (test for trend p=0.041). No gender difference between MACE and BMI could be noticed (p=0.16). A higher risk for MACE was indicated in group BMI ≤18.5kg/m(2) in comparison to group BMI 25.0-29.9kg/m(2) (OR: 7.93; 95% CI: 1.75-35.89; p=0.0091), whereas group BMI 30.0-34.9kg/m(2) was significant associated with a lower risk in comparison to group BMI 25.0-29.9kg/m(2) (OR: 0.65; 95% CI: 0.21-1.96; p=0.044). An association between HDL-c (p=0.55) or LDL-c (p=0.10) and MACE could not be detected.

CONCLUSION:

The study demonstrates that patients with STEMI and a BMI of 30.0-34.9kg/m(2) have a decreased risk for MACE compared to patients with normal BMI. No gender related differences were indicated. An association between MACE and lipoproteins could not be detected.

• Authors: Stefan Baumann, Johanna Koepp, Tobias Becher, Aydin Huseynov, Katharina Bosch, Michael Behnes, Christian Fastner, Ibrahim El-Battrawy, Matthias Renker, Siegfried Lang, Christel Weiß, Martin Borggrefe, Ralf Lehmann, Ibrahim Akin
• Journal: Cardiovascular revascularization medicine : including molecular interventions (Cardiovasc Revasc Med) Vol. 17 Issue 2 Pg. 88-94 (Mar 2016) ISSN: 1878-0938 [Electronic] United States
• PMID: 26895953 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2016 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• Cholesterol, HDL
• Cholesterol, LDL

Topics

• Aged
• Biomarkers (blood)
• Body Mass Index
• Chi-Square Distribution
• Cholesterol, HDL (blood)
• Cholesterol, LDL (blood)
• Female
• Humans
• Logistic Models
• Male
• Middle Aged
• Multivariate Analysis
• Nutritional Status
• Obesity (blood, complications, diagnosis, physiopathology)
• Odds Ratio
• Percutaneous Coronary Intervention (adverse effects)
• Protective Factors
• Retrospective Studies
• Risk Factors
• ST Elevation Myocardial Infarction (diagnosis, etiology, therapy)
• Sex Factors
• Time Factors
• Treatment Outcome