Oxidative stress has been implicated in the pathogenesis of
hyperthyroidism and its complications. Interaction of
advanced glycation end products (AGEs) with receptor RAGE (receptor for AGEs) generates
reactive oxygen species. Soluble receptor for AGEs (sRAGE) competes with RAGE for binding with AGEs and attenuates the generation of ROS. Low levels sRAGE and high levels AGEs would generate more ROS leading to
hyperthyroidism and its complications. The objectives are to determine if levels of serum sRAGE are low and the levels of AGEs and AGEs/sRAGE are high in patients with
hyperthyroidism. The study subjects comprised of 33 patients with
hyperthyroidism and 20 controls. Levels of serum sRAGE were lower, while that of AGEs and AGEs/sRAGE were higher in patients compared to controls, being significant only for sRAGE and AGEs/sRAGE. When the levels of sRAGE, AGEs, and AGEs/sRAGE were assessed for
hyperthyroidism associated with different diseases, the levels of sRAGE were lower in
Hashimoto disease, and levels of AGEs were higher in patients with
Graves' disease compared to control. The levels of AGEs/sRAGE were elevated in an all except patients with
Hashimoto disease. The levels of AGEs, sRAGE, or AGEs/RAGE were not correlated with age, weight, and blood pressures except systolic pressure which was inversely correlated with sRAGE. The levels of sRAGE were negatively correlated with AGEs and AGEs/sRAGE. The levels of AGEs/sRAGE were positively correlated with AGEs. In conclusion, low levels of sRAGE, and high levels of AGEs and AGEs/sRAGE are risk
biomarkers in the pathogenesis
hyperthyroidism and its complications.