Prenatal, perinatal, and childhood vitamin D exposure and their association with childhood allergic rhinitis and allergic sensitization.

Abstract

BACKGROUND:

The role of early-life vitamin D in childhood allergy is controversial.

OBJECTIVE:

We sought to assess vitamin D exposure in early life by multiple modalities and ascertain its association with childhood allergic rhinitis and allergic sensitization.

METHODS:

One thousand two hundred forty-eight mother-child pairs from a US prebirth cohort unselected for any disease were studied. Vitamin D exposure was assessed by measures of maternal intake during the first and second trimesters of pregnancy and serum 25-hydroxyvitamin D (25[OH]D) levels in mothers during pregnancy, cord blood, and children at school age (median age, 7.7 years; interquartile range, 1.0 years). Tests for associations between vitamin D exposure with ever allergic rhinitis, serum total IgE level, and allergen sensitization at school age were conducted.

RESULTS:

The correlations between maternal intake of vitamin D during pregnancy and serum 25(OH)D levels in pregnant mothers, cord blood, and children at school age were weak to moderate (r = -0.03 to 0.53). Each 100 IU/d of food-based vitamin D intake during the first and second trimesters (equivalent to the amount of vitamin D in an 8-ounce serving of milk) was associated with 21% and 20% reduced odds of ever allergic rhinitis at school age (odds ratios of 0.79 [95% CI, 0.67-0.92] and 0.80 [95% CI, 0.68-0.93]), respectively. There were no associations between maternal supplemental vitamin D intake or serum 25(OH)D levels at any time point with ever allergic rhinitis. There were no associations between any vitamin D exposure and serum total IgE level or allergen sensitization at school age.

CONCLUSIONS:

Inclusion of foods containing vitamin D in maternal diets during pregnancy may have beneficial effects on childhood allergic rhinitis.

• Authors: Supinda Bunyavanich, Sheryl L Rifas-Shiman, Thomas A Platts-Mills, Lisa Workman, Joanne E Sordillo, Carlos A Camargo Jr, Matthew W Gillman, Diane R Gold, Augusto A Litonjua
• Journal: The Journal of allergy and clinical immunology (J Allergy Clin Immunol) Vol. 137 Issue 4 Pg. 1063-1070.e2 (Apr 2016) ISSN: 1097-6825 [Electronic] United States
• PMID: 26874366 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2016 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• Vitamins
• Vitamin D
• 25-hydroxyvitamin D

Topics

• Biomarkers (blood)
• Child
• Diet
• Dietary Supplements (statistics & numerical data)
• Female
• Fetal Blood (metabolism)
• Humans
• Infant, Newborn
• Longitudinal Studies
• Male
• Pregnancy
• Prenatal Exposure Delayed Effects (blood, etiology, prevention & control)
• Prenatal Nutritional Physiological Phenomena
• Prospective Studies
• Rhinitis, Allergic (blood, etiology, prevention & control)
• Vitamin D (analogs & derivatives, blood)
• Vitamins (therapeutic use)