Abstract | BACKGROUND: Previous studies suggest that certain transition metal complexes, such as cisplatin, are efficacious for treating various cancer types, including ovarian, lung, and breast. METHODS: In order to further evaluate ruthenium (Ru) complexes as potential anti- cancer agents, we synthesized and evaluated Ru-arene complexes. Two complexes with the general formula [Ru (η (6)-p-cym) (N-N) Cl](+) were tested for their abilities to inhibit cancer cells. RESULTS: The complex with o-phenylenediamine as the N-N ligand (o-PDA) significantly inhibited growth of breast (MDA-MB-231, MCF-7, SKBR-3, and SUM149), lymphoma (Raji), melanoma (Bowes), and osteosarcoma (HT1080); however, the complex with o-benzoquinonediimine (o-BQDI) was ineffective except for SUM149. In contrast, o-PDA failed to inhibit growth of human breast epithelial cells, MCF-10A. Treatment of MDA-MBA-231 cells with o-PDA resulted in a significant reduction of productions of PDGF-AA, GM-CSF, and VEGF-A proteins at the transcriptional levels. Finally, we demonstrated that o-PDA synergistically inhibited MDA-MB-231 cell growth with cyclophosphamide but not doxorubicin or paclitaxel. CONCLUSION: These results suggest that Ru-arene complexes are promising anti- cancer drugs that inhibit progression and metastasis by blocking multiple processes for breast and other types of cancer.
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Authors | Joji Iida, Elisabeth T Bell-Loncella, Marc L Purazo, Yifeng Lu, Jesse Dorchak, Rebecca Clancy, Julianna Slavik, Mary Lou Cutler, Craig D Shriver |
Journal | Journal of translational medicine
(J Transl Med)
Vol. 14
Pg. 48
(Feb 12 2016)
ISSN: 1479-5876 [Electronic] England |
PMID | 26867596
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Antineoplastic Agents
- Coordination Complexes
- Intercellular Signaling Peptides and Proteins
- Phenylenediamines
- Ruthenium
- 1,2-diaminobenzene
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Topics |
- Antineoplastic Agents
(pharmacology, therapeutic use)
- Breast Neoplasms
(drug therapy, pathology)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Coordination Complexes
(chemistry, pharmacology, therapeutic use)
- Female
- Humans
- Intercellular Signaling Peptides and Proteins
(biosynthesis)
- Phenylenediamines
(pharmacology)
- Ruthenium
(chemistry, pharmacology, therapeutic use)
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