Heterozygous congenital Factor VII deficiency with the 9729del4 mutation, associated with severe spontaneous intracranial bleeding in an adolescent male.

Abstract

BACKGROUND:

In congenital Factor (F) VII deficiency bleeding phenotype and intrinsic FVII activity levels don't always correlate. Patients with FVII activity levels <30% appear to have a higher bleeding propensity, but bleeding can also occur at higher FVII activity levels. Reasons for bleeding at higher FVII activity levels are unknown, and it remains challenging to manage such patients clinically.

CASE:

A 19year old male with spontaneous intracranial hemorrhage and FVII activity levels of 44%, requiring emergent surgical intervention and a strategy for FVII replacement. Genotyping showed the rare heterozygous FVII 9729del4 mutation. Bleed evacuation was complicated by epidural abscess requiring craniectomy, bone graft procedures, and prolonged administration of recombinant human (rh) activated FVII (FVIIa). The patient recovered without neurological deficits, and remains on prophylactic low dose treatment with rhFVIIa in relation to risky athletic activities.

CONCLUSION:

For clinicians, it is important to recognize that effects of rhFVIIa within these pathways are independent of its contribution to blood clot formation and cannot be assessed by clotting assays. Reduced FVII levels should therefore not be dismissed, as even a mild reduction may result in spontaneous bleeding. Treatment of mild FVII deficiency requires a careful case-by-case approach, based on the clinical scenario.

• Authors: Thomas J Cramer, Kristin Anderson, Karanjia Navaz, Justin M Brown, Laurent O Mosnier, Annette von Drygalski
• Journal: Blood cells, molecules & diseases (Blood Cells Mol Dis) Vol. 57 Pg. 8-12 (Mar 2016) ISSN: 1096-0961 [Electronic] United States
• PMID: 26852649 (Publication Type: Case Reports, Journal Article, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Chemical References

• Recombinant Proteins
• Factor VII
• Factor VIIa

Topics

• Base Sequence
• Bone Transplantation
• Cerebral Hemorrhage (complications, genetics, pathology, therapy)
• DNA Mutational Analysis
• Decompressive Craniectomy
• Epidural Abscess (complications, genetics, pathology, therapy)
• Factor VII (genetics)
• Factor VII Deficiency (complications, genetics, pathology, therapy)
• Factor VIIa (therapeutic use)
• Gene Expression
• Heterozygote
• Humans
• Male
• Molecular Sequence Data
• Recombinant Proteins (therapeutic use)
• Sequence Deletion
• Young Adult