Biological Evaluation of Ferrocenyl Olefins: Cancer Cell Growth Inhibition, ROS Production, and Apoptosis Activity.

Abstract

The antiproliferative effects of various ferrocenyl olefins were evaluated against the cell lines MCF-7 (human breast cancer cells), DLD-1 (human colon adenocarcinoma cells), HUVEC (human umbilical vein endothelial cells), and A549 (human lung carcinoma cells), using the MTT test. IC50 values were determined. Compounds 8, 9, 11, and 12 with high antiproliferative activity were tested for their reactive oxygen species (ROS) production, and cell cycle analysis was performed on A549 cells. The results show that these compounds might perform their antiproliferative activity through inducing ROS generation, apoptosis induction, and cell cycle arrest.

• Authors: Aijing Sun, Junsheng Lin, Chao Pi, Ruian Xu, Xiuling Cui
• Journal: Archiv der Pharmazie (Arch Pharm (Weinheim)) Vol. 349 Issue 3 Pg. 186-92 (Mar 2016) ISSN: 1521-4184 [Electronic] Germany
• PMID: 26841261 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Alkenes
• Antineoplastic Agents
• Ferrous Compounds
• Metallocenes
• Reactive Oxygen Species
• ferrocene

Topics

• Alkenes (chemical synthesis, chemistry, pharmacology)
• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
• Apoptosis (drug effects)
• Cell Cycle Checkpoints (drug effects)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Drug Screening Assays, Antitumor
• Ferrous Compounds (chemical synthesis, chemistry, pharmacology)
• Human Umbilical Vein Endothelial Cells
• Humans
• Metallocenes
• Reactive Oxygen Species (metabolism)
• Structure-Activity Relationship