CD133 Expression at the Metastatic Site Predicts Patients' Outcome in Colorectal Cancer with Synchronous Liver Metastasis.

Abstract

BACKGROUND:

CD133 is a transmembrane protein that is proposed to be a stem cell marker of colorectal cancer (CRC); however, the correlation between CD133 expression and survival of CRC patients with liver metastasis has not been fully examined.

METHODS:

CD133 expression was evaluated immunohistochemically, both in primary tumors and synchronous liver metastases of 88 consecutive CRC patients, as well as recurrent lesions in the remnant liver of 27 of these 88 patients. The relationship between CD133 expression and clinicopathological characteristics, recurrence-free survival, and overall survival (OS) was analyzed.

RESULTS:

CD133 expression in liver metastases (mCD133) was detected in 50 of 88 patients (56.8 %), and had significant correlation with CD133 expression in primary lesions (pCD133) (p < 0.001). CD133 expression in liver recurrent lesions (recCD133) also had a significant correlation with mCD133 (p < 0.001). mCD133+ patients had significantly longer disease-free survival (p = 0.043) and OS (p = 0.014) than mCD133- patients. In addition, mCD133+ patients had a significantly lower rate of extrahepatic recurrence (p < 0.001).

CONCLUSIONS:

Patients without CD133 expression in liver metastasis had significantly shorter survival, perhaps because mCD133- patients had a significantly higher rate of extrahepatic recurrence.

• Authors: Junko Kishikawa, Shinsuke Kazama, Koji Oba, Kiyoshi Hasegawa, Hiroyuki Anzai, Yuzo Harada, Hiroyuki Abe, Keisuke Matsusaka, Kumiko Hongo, Masaru Oba, Koji Yasuda, Kensuke Otani, Takeshi Nishikawa, Toshiaki Tanaka, Junichiro Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Kazushige Kawai, Hiroaki Nozawa, Hironori Yamaguchi, Soichiro Ishihara, Eiji Sunami, Tetsuo Ushiku, Joji Kitayama, Masashi Fukayama, Norihiro Kokudo, Toshiaki Watanabe
• Journal: Annals of surgical oncology (Ann Surg Oncol) Vol. 23 Issue 6 Pg. 1916-23 (06 2016) ISSN: 1534-4681 [Electronic] United States
• PMID: 26832881 (Publication Type: Journal Article)

Chemical References

• AC133 Antigen
• Biomarkers, Tumor
• PROM1 protein, human

Topics

• AC133 Antigen (metabolism)
• Biomarkers, Tumor (metabolism)
• Colorectal Neoplasms (metabolism, mortality, pathology, surgery)
• Follow-Up Studies
• Humans
• Liver Neoplasms (metabolism, mortality, secondary, surgery)
• Neoplasm Recurrence, Local (metabolism, mortality, pathology, surgery)
• Neoplasms, Multiple Primary (metabolism, mortality, secondary, surgery)
• Prognosis
• Survival Rate