Abstract | BACKGROUND: OBJECTIVE: This study was designed to investigate the association between maternal SZC during pregnancy and risk of preterm birth. METHODS: For this substudy of the China-Anhui Birth Cohort Study, 3081 maternal-singleton pairs with detailed birth records and available serum samples were identified. The maternal SZC was determined with flame atomic absorption spectroscopy. A total of 169 preterm births were identified. In this study, the women were divided into tertiles on the basis of their SZC: low (<76.7 μg/dL), medium (76.7-99.6 μg/dL), and high (≥99.7 μg/dL). The ORs for preterm birth were estimated by using multiple logistic regression models. RESULTS: The median SZC was 87.3 μg/dL (range: 11.1-211 μg/dL). Incidences of preterm birth were 7.3% and 6.0% among subjects with low and medium SZCs, respectively, which were significantly higher than 3.1% among subjects with a high SZC [ ORs (95% CIs) for low and medium SZCs: 2.45 (1.60, 3.74), P < 0.001, and 2.00 (1.29, 3.09), P < 0.01, respectively]. After adjustment for prepregnancy body mass index, maternal age, time of serum collection, gravidity, parity, and monthly income, adjusted ORs were 2.41 (95% CI: 1.57, 3.70; P < 0.001) and 1.97 (95% CI: 1.27, 3.05; P < 0.01) among subjects with low and medium maternal SZCs. CONCLUSIONS: Maternal serum zinc concentration during pregnancy is inversely associated with risk of preterm birth in the Chinese population, and the results are driven by maternal SZC in the first trimester.
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Authors | Hua Wang, Yong-Fang Hu, Jia-Hu Hao, Yuan-Hua Chen, Ying Wang, Peng Zhu, Cheng Zhang, Yuan-Yuan Xu, Fang-Biao Tao, De-Xiang Xu |
Journal | The Journal of nutrition
(J Nutr)
Vol. 146
Issue 3
Pg. 509-15
(Mar 2016)
ISSN: 1541-6100 [Electronic] United States |
PMID | 26817714
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2016 American Society for Nutrition. |
Chemical References |
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Topics |
- Adult
- Asian People
- Body Mass Index
- China
(epidemiology)
- Female
- Humans
- Incidence
- Infant, Newborn
- Logistic Models
- Nutritional Status
- Pregnancy
- Premature Birth
(blood, epidemiology)
- Prospective Studies
- Risk Factors
- Socioeconomic Factors
- Young Adult
- Zinc
(blood)
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