Abstract | BACKGROUND & AIMS: METHODS: Twelve adults with ADPKD enrolled in a pre-post pilot feasibility study and served as their own controls. Individuals consumed their usual diet for one week then for four weeks followed an isocaloric diet lower in sodium and protein and higher in fruits, vegetables, and water. Three-day diet records and two 24-h urine samples were collected at baseline, week 2, and week 4 visits; blood pressure, weight, and serum were obtained at all three visits. A modified nutrition hassles questionnaire was completed on the last visit. RESULTS: During the dietary intervention, subjects (n = 11) consumed less sodium, protein, and dietary acid precursors 36%, 28%, and 99%, respectively, and increased fluid intake by 42%. Urinary sodium, urea, net acid excretion, osmoles, and osmolality decreased 20%, 28%, 20%, 37%, and 15%, respectively; volume increased 35%. Urine changes were in accord with the diet record. Ninety-one percent of participants reported that none of the hassles were worse than "somewhat severe", and most participants felt "somewhat confident" or "very confident" that they could manage the new diet. CONCLUSIONS: A majority of adult patients with ADPKD successfully prepared and followed a composite diet prescription with decreased sodium, protein, acid precursors, and increased fluid intake. This trail was registered at ClinicalTrials.gov (NCT01810614).
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Authors | Jacob M Taylor, Jill M Hamilton-Reeves, Debra K Sullivan, Cheryl A Gibson, Catherine Creed, Susan E Carlson, Donald E Wesson, Jared J Grantham |
Journal | Clinical nutrition (Edinburgh, Scotland)
(Clin Nutr)
Vol. 36
Issue 2
Pg. 458-466
(04 2017)
ISSN: 1532-1983 [Electronic] England |
PMID | 26811129
(Publication Type: Clinical Trial, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. |
Chemical References |
- Dietary Proteins
- Sodium Chloride, Dietary
- Urea
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Topics |
- Adult
- Cohort Studies
- Cross-Sectional Studies
- Diet
- Diet Records
- Dietary Proteins
(administration & dosage)
- Feasibility Studies
- Female
- Fruit
- Humans
- Male
- Middle Aged
- Osmolar Concentration
- Pilot Projects
- Polycystic Kidney, Autosomal Dominant
(diet therapy)
- Sodium Chloride, Dietary
(administration & dosage, urine)
- Surveys and Questionnaires
- Urea
(urine)
- Vegetables
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