[A Case of Unresectable Rectal Cancer Associated with Hemorrhage of the Primary Tumor after Chemotherapy].

Abstract

A 47-year-old man visited our hospital with complaints of abdominal pain and hematuria.He was diagnosed with unresectable rectal cancer invading the urinary bladder with multiple liver metastases. Systemic chemotherapy with mFOLFOX6 and panitumumab was started soon after sigmoid colostomy. Three months later, both the primary tumor and the liver metastases had partially responded. Another 2 months later, he complained of terrible abdominal pain. CT images revealed a huge primary tumor and hemorrhage in the sigmoid mesocolon occupying the pelvic cavity. A salvage operation was performed and the primary tumor was palliatively resected. Soon after the operation, a local recurrence appeared and grew rapidly. He died 8 months after diagnosis. Rapid growth of the primary tumor seemed a limiting factor for the prognosis.

• Authors: Moyuru Yamada, Hidekazu Takahashi, Masaru Murata, Nobuo Tanaka, Kensuke Asai, Kazuhiro Saso, Tomoko Yagi, Shinsuke Katsuyama, Hirokazu Sawami, Osamu Takayama, Masashi Baba, Masayuki Yamamoto, Masahiro Hiratsuka
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 42 Issue 12 Pg. 1659-61 (Nov 2015) ISSN: 0385-0684 [Print] Japan
• PMID: 26805129 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Fatal Outcome
• Hemorrhage (chemically induced)
• Humans
• Liver Neoplasms (drug therapy, secondary)
• Male
• Middle Aged
• Neoplasm Invasiveness
• Rectal Neoplasms (drug therapy, pathology, surgery)
• Salvage Therapy