Abstract | BACKGROUND: Relative wall thickness (RWT), defined as 2 times posterior wall thickness divided by the left ventricular (LV) diastolic diameter, is a measure of LV geometry and may be a marker for adverse events in patients with LV dysfunction. OBJECTIVES: METHODS: RESULTS: In a multivariable model, RWT was the most powerful echocardiographic measure for estimating the risk of VAs compared with commonly used echocardiographic variables. Patients with low RWT (<0.24) had 83% (p < 0.001) increased risk for VA and 68% (p < 0.001) increase in VA risk or death (VA/death) compared with patients with higher RWT values. Each 0.01-unit decrease in RWT was associated with 12% (p < 0.001) and 10% (p < 0.001) increases in the risk of VA and VA/death, respectively. Treatment with cardiac resynchronization therapy with defibrillator (CRT-D; CRT with implantable cardioverter-defibrillator) was associated with a greater increase in RWT compared with implantable cardioverter-defibrillator at 12 months (4.6 ± 6.8% vs. 1.5 ± 2.7%; p < 0.001), and every 10% increase in RWT in CRT-D patients was associated with 34% (p = 0.027) and 36% (p = 0.009) reductions in the risk of subsequent VA and VA/death, respectively. CONCLUSIONS:
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Authors | Yitschak Biton, Ilan Goldenberg, Valentina Kutyifa, Jayson R Baman, Scott Solomon, Arthur J Moss, Barbara Szepietowska, Scott McNitt, Bronislava Polonsky, Wojciech Zareba, Alon Barsheshet |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 67
Issue 3
Pg. 303-12
(Jan 26 2016)
ISSN: 1558-3597 [Electronic] United States |
PMID | 26796396
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Topics |
- Aged
- Bundle-Branch Block
(complications)
- Cardiac Resynchronization Therapy
(adverse effects, methods)
- Defibrillators, Implantable
(adverse effects)
- Echocardiography
(methods)
- Female
- Heart Failure
(complications, diagnosis, therapy)
- Heart Ventricles
(pathology)
- Humans
- Male
- Middle Aged
- Organ Size
- Outcome Assessment, Health Care
- Risk Assessment
(methods)
- Risk Factors
- Statistics as Topic
- Tachycardia, Ventricular
(epidemiology, etiology, prevention & control)
- Ventricular Dysfunction, Left
(diagnosis, etiology, physiopathology)
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