Abstract | BACKGROUND: CASE PRESENTATION: A 27-year old female presented with clinical and biochemical thyrotoxicosis with a previous history chemo- and radiotherapy (including the neck region) for a Hodgkin's lymphoma (at the age of 18). At the age of 20 this was followed by severe hypothyrodism [TSH > 100 μIU/mL (reference range: 0.27-4.2)]. She was stated on L-thyroxine, but the dose was later reduced and subsequently discontinued. She had significantly elevated titres of both anti- thyroid peroxidase antibodies and anti- TSH-receptor antibodies throughout the course of disease. Thyroid scintigraphy revealed a normal and homogenous iodine uptake. CONCLUSIONS: We suspect that a gradual switch from thyroid-blocking to thyroid-stimulating antibodies resulted in development of an overt thyrotoxicosis, possibly with a contributory effect of neck irradiation on her autoimmune status.
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Authors | Krzysztof Lewandowski, Katarzyna Dąbrowska, Jacek Makarewicz, Andrzej Lewiński |
Journal | Thyroid research
(Thyroid Res)
Vol. 9
Pg. 1
( 2016)
ISSN: 1756-6614 [Print] England |
PMID | 26779284
(Publication Type: Case Reports)
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