Long-term survival, valve durability, and reoperation for 4 aortic root procedures combined with ascending aorta replacement.

Abstract

OBJECTIVE:

To evaluate long-term results of aortic root procedures combined with ascending aorta replacement for aneurysms, using 4 surgical strategies.

METHODS:

From January 1995 to January 2011, 957 patients underwent 1 of 4 aortic root procedures: valve preservation (remodeling or modified reimplantation, n = 261); composite biologic graft (n = 297); composite mechanical graft (n = 156); or allograft root (n = 243).

RESULTS:

Seven deaths occurred (0.73%), none after valve-preserving procedures, and 13 strokes (1.4%). Composite grafts exhibited higher gradients than allografts or valve preservation, but the latter 2 exhibited more aortic regurgitation (2.7% biologic and 0% mechanical composite grafts vs 24% valve-preserving and 19% allografts at 10 years). Within 2 to 5 years, valve preservation exhibited the least left ventricular hypertrophy, allograft replacement the greatest; however, valve preservation had the highest early risk of reoperation, allograft replacement the lowest. Patients receiving allografts had the highest risk of late reoperation (P < .05), and those receiving composite mechanical grafts and valve preservation had the lowest. Composite bioprosthesis patients had the highest risk of late death (57% at 15 years vs 14%-26% for the remaining procedures, P < .0001), because they were substantially older and had more comorbidities (P < .0001).

CONCLUSIONS:

These 4 aortic root procedures, combined with ascending aorta replacement, provide excellent survival and good durability. Valve-preserving and allograft procedures have the lowest gradients and best ventricular remodeling, but they have more late regurgitation, and likely, less risk of valve-related complications, such as bleeding, hemorrhage, and endocarditis. Despite the early risk of reoperation, we recommend valve-preserving procedures for young patients when possible. Composite bioprostheses are preferable for the elderly.

• Authors: Lars G Svensson, Saila T Pillai, Jeevanantham Rajeswaran, Milind Y Desai, Brian Griffin, Richard Grimm, Donald F Hammer, Maran Thamilarasan, Eric E Roselli, Gösta B Pettersson, A Marc Gillinov, Jose L Navia, Nicholas G Smedira, Joseph F Sabik 3rd, Bruce W Lytle, Eugene H Blackstone
• Journal: The Journal of thoracic and cardiovascular surgery (J Thorac Cardiovasc Surg) Vol. 151 Issue 3 Pg. 764-774.e4 (Mar 2016) ISSN: 1097-685X [Electronic] United States
• PMID: 26778214 (Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Video-Audio Media)
• Copyright: Copyright © 2016 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.

Topics

• Age Factors
• Allografts
• Aortic Aneurysm (diagnosis, mortality, surgery)
• Aortic Valve (physiopathology, transplantation)
• Bioprosthesis
• Blood Vessel Prosthesis
• Blood Vessel Prosthesis Implantation (adverse effects, instrumentation, mortality)
• Heart Valve Prosthesis
• Heart Valve Prosthesis Implantation (adverse effects, instrumentation, mortality)
• Hospital Mortality
• Humans
• Patient Selection
• Postoperative Complications (mortality, surgery)
• Prosthesis Design
• Registries
• Reoperation
• Replantation
• Risk Assessment
• Risk Factors
• Time Factors
• Treatment Outcome