Complications in thyroid surgery. Harmonic Scalpel, Harmonic Focus versus Conventional Hemostasis: A meta-analysis.

Abstract

BACKGROUND:

To evaluate the incidence of postoperative complications, hemostatic effects and safety of Total Thyroidectomy (TT) performed using the Harmonic Scalpel (HS), the Harmonic Focus (HF) or Conventional Hemostasis (CH).

METHODS:

The meta-analysis was performed according to PRISMA guidelines. A literature search was conducted from 2003 to 2014 and stringent criteria were required for inclusion. Thirteen studies concerning an overall population of 1458 compared HS versus CH, whilst 8 studies with 1667 patients compared HF versus CH.

RESULTS:

There was a significant reduction of operative time (Mean Difference [MD] = -25.49 min.; 95% CI -32.43 to -18.55), intraoperative blood loss (MD = -30.49 mL; 95% CI -53.01 to -7.97), postoperative drainage volume (MD = -12.90 mL; 95% CI -22.83 to -2.98) and postoperative pain (MD = -0.87; 95% CI -1.27 to -0.46) in patients underwent TT with HS. Regarding HF group, a significant reduction of operative time (MD = -25.99 min., 95% CI -34.56 to -17.41), length of hospital stay (MD = -0.57; 95% CI -0.97 to -0.17), transient hypocalcemia (OR = 0.56; 95% CI 0.39 to 0.81) and postoperative pain (MD = -1.33 days; 95% CI -2.49 to -0.17) resulted.

CONCLUSIONS:

HS TT can be a safe, useful and fast alternative to conventional TT. The newer HF can reduce the rate of hypocalcemia. Future RCTs of larger patient cohorts with more detailed data of postoperative complications, cost-effectiveness and cosmetic results, randomization procedures, intention-to-treat analyses and blinding of outcome assessors are needed to draw more meaningful conclusions.

• Authors: Luca Revelli, Gianfranco Damiani, Caterina Bianca Neve Aurora Bianchi, Serafino Vanella, Walter Ricciardi, Marco Raffaelli, Celestino Pio Lombardi
• Journal: International journal of surgery (London, England) (Int J Surg) Vol. 28 Suppl 1 Pg. S22-32 (Apr 2016) ISSN: 1743-9159 [Electronic] England
• PMID: 26768409 (Publication Type: Journal Article, Meta-Analysis, Review)
• Copyright: Copyright © 2015 IJS Publishing Group Limited. Published by Elsevier Ltd. All rights reserved.

Topics

• Blood Loss, Surgical (prevention & control)
• Drainage
• Female
• Hemostasis, Surgical (instrumentation, methods)
• Humans
• Length of Stay
• Operative Time
• Postoperative Complications (etiology, prevention & control)
• Postoperative Period
• Surgical Instruments
• Thyroid Gland (surgery)
• Thyroidectomy (adverse effects, instrumentation, methods)