[A Case of Anti-GQ1b Antibody Syndrome Associated with Pure Bilateral Adie's Pupils].

Abstract

A 37 year-old Japanese male felt photophobia of both eyes one week following the onset of the common cold. His neurological examination revealed bilateral Adie's tonic pupils, no extraocular movement disorder, normal deep tendon reflexes, and no cerebellar signs. Based on markedly increased blood levels of anti-GQ1b IgG and anti-GT1a IgG antibodies, we diagnosed him as anti-GQ1b antibody syndrome. Bilateral Adie's tonic pupils were improved by IVIg drip infusion and methylprednisolone pulse therapy. This case suggests that we need to investigate anti ganglioside antibody when a patient presents with bilateral Adie's tonic pupils.

• Authors: Shunsuke Kajikawa, Takekazu Ohi, Atsushi Fujita, Susumu Kusunoki
• Journal: Brain and nerve = Shinkei kenkyu no shinpo (Brain Nerve) Vol. 68 Issue 1 Pg. 93-6 (Jan 2016) ISSN: 1881-6096 [Print] Japan
• PMID: 26764303 (Publication Type: Case Reports, English Abstract, Journal Article, Review)

Chemical References

• Antibodies

Topics

• Adult
• Antibodies (immunology)
• Eye (immunology)
• Humans
• Infusions, Intravenous (methods)
• Male
• Syndrome
• Tonic Pupil (diagnosis, immunology, therapy)