Recent advances in the determination of tocopherols in biological fluids: from sample pretreatment and liquid chromatography to clinical studies.

Abstract

Vitamin E comprises eight related compounds: α-, β-, γ-, δ-tocopherols and α-, β-, γ-, δ-tocotrienols. In the past, α-tocopherol has been the isomer that was studied most, and its anti-inflammatory and anti-proliferative effects have been described. Therefore, many prevention trials have investigated the effect of α-tocopherol on human health. Current research studies have also defined the important roles of other tocopherols, such as anti-inflammatory, anti-proliferative and cancer preventative effects. Knowledge of the individual tocopherols could help to understand their roles in various metabolic pathways. This review summarizes the recent trends in sample pretreatment, liquid chromatography and selected applications of the determination of tocopherols in various biological materials. The relationship between tocopherol isomers and serious diseases is also described. Graphical Abstract Article structure.

• Authors: Barbora Cervinkova, Lenka Kujovska Krcmova, Dagmar Solichova, Bohuslav Melichar, Petr Solich
• Journal: Analytical and bioanalytical chemistry (Anal Bioanal Chem) Vol. 408 Issue 10 Pg. 2407-24 (Apr 2016) ISSN: 1618-2650 [Electronic] Germany
• PMID: 26758599 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Tocopherols

Topics

• Body Fluids (chemistry)
• Chromatography, High Pressure Liquid (methods)
• Humans
• Tocopherols (analysis)