Comparison of three ¹⁸F-labeled carboxylic acids with ¹⁸F-FDG of the differentiation tumor from inflammation in model mice.

Abstract

BACKGROUND:

The aim of this study was to compare the properties and feasibility of the glucose analog, 2-(18)F-fluoro-2-deoxy-D-glucose ((18)F-FDG), three short (18)F-labeled carboxylic acids, (18)F-fluoroacetate ((18)F-FAC), 2-(18)F-fluoropropionic acid ((18)F-FPA) and 4-((18)F)fluorobenzoic acid ((18)F-FBA), for differentiating tumors from inflammation.

METHODS:

Biodistributions of (18)F-FAC, (18)F-FPA and (18)F-FBA were determined on normal Kunming mice, and positron emission tomography (PET) imaging with these tracers were performed on the separate tumor-bearing mice model and inflammation mice model in comparison with (18)F-FDG.

RESULTS:

Biodistribution results showed that (18)F-FAC and (18)F-FPA had similar biodistribution profiles and the slow radioactivity clearance from most tissues excluding the in vivo defluorination of (18)F-FAC, and (18)F-FBA demonstrated a lower uptake and fast clearance in most tissues. PET imaging with (18)F-FDG, (18)F-FAC and (18)F-FPA revealed the high uptake in both tumor and inflammatory lesions. The ratios of tumor-to-inflammation were 1.63 ± 0.28 for (18)F-FDG, 1.20 ± 0.38 for (18)F-FAC, and 1.41 ± 0.33 for (18)F-FPA at 60 min postinjection, respectively. While clear tumor images with high contrast between tumor and inflammation lesion were observed in (18)F-FBA/PET with the highest ratio of tumor-to-inflammation (1.98 ± 0.15).

CONCLUSIONS:

Our data demonstrated (18)F-FBA is a promising PET probe to distinguish tumor from inflammation. But the further modification of (18)F-FBA structure is required to improve its pharmacokinetics.

• Authors: Hongliang Wang, Ganghua Tang, Kongzhen Hu, Tingting Huang, Xiang Liang, Zhifang Wu, Sijin Li
• Journal: BMC medical imaging (BMC Med Imaging) Vol. 16 Pg. 2 (Jan 12 2016) ISSN: 1471-2342 [Electronic] England
• PMID: 26754531 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 2-18F-fluoropropionic acid
• Benzoates
• Carboxylic Acids
• Fluoroacetates
• Fluorocarbons
• Radiopharmaceuticals
• Fluorodeoxyglucose F18
• fluoroacetic acid

Topics

• Animals
• Benzoates (pharmacokinetics)
• Carboxylic Acids (pharmacokinetics)
• Diagnosis, Differential
• Disease Models, Animal
• Fluoroacetates (pharmacokinetics)
• Fluorocarbons (pharmacokinetics)
• Fluorodeoxyglucose F18 (pharmacokinetics)
• Humans
• Inflammation (diagnosis)
• Mice
• Neoplasms (diagnosis)
• Positron-Emission Tomography (methods)
• Radiopharmaceuticals (pharmacokinetics)
• Tissue Distribution