Xenotropic Murine Leukemia Virus-Related Virus and RNase L R462Q Variants in Iranian Patients With Sporadic Prostate Cancer.

Abstract

BACKGROUND:

Although several studies have confirmed the association of xenotropic murine leukemia virus-related virus (XMRV) and prostate cancer, this association is still controversial, as most studies did not detect XMRV in prostate tissue samples. Furthermore, some genetic and epidemiological studies have highlighted a role for RNase L polymorphisms, particularly R462Q, in the progression of prostate cancer.

OBJECTIVES:

The focus of this study was on the association of XMRV and RNase L R462Q variants with the risk of prostate cancer in Iranian patients.

PATIENTS AND METHODS:

In this case-control study, 40 and 80 individuals with sporadic prostate cancer and benign prostatic hyperplasia, respectively, were included. The presence of XMRV was evaluated by real-time polymerase chain reaction (PCR) of integrase and nested-PCR for the gag genes. The RNase L R462Q polymorphism analysis was carried out by PCR and sequencing.

RESULTS:

In a total of 40 sporadic prostate cancer and 80 benign prostatic hyperplasia cases, no XMRV was detected by real-time PCR and nested-PCR. RNase L R462Q polymorphism analysis reveals that although there was an increase in the risk of prostate cancer correlated with the Q/Q allele of RNase L at position 462, the frequencies of the RNase L R462Q alleles were not statistically significant between the prostate cancer and benign prostatic hyperplasia groups (OR = 2.75 (95% CI = 0.67 - 11.3), P = 0.29).

CONCLUSIONS:

These results did not support the presence of XMRV in the samples with prostate cancer and showed that RNase L R462Q variants had relatively little or no impact on the risk of prostate cancer in Iranian population.

• Authors: Farhad Babaei, Ali Ahmadi, Farhad Rezaei, Somayeh Jalilvand, Nastaran Ghavami, Mahmoud Mahmoudi, Ramin Abiri, Nasim Kondori, Rakhshande Nategh, Talat Mokhtari Azad
• Journal: Iranian Red Crescent medical journal (Iran Red Crescent Med J) Vol. 17 Issue 12 Pg. e19439 (Dec 2015) ISSN: 2074-1804 [Print] Estonia
• PMID: 26744630 (Publication Type: Journal Article)