Association of the XPD and XRCC3 gene polymorphisms with oral squamous cell carcinoma in a Northeastern Brazilian population: A pilot study.

Abstract

OBJECTIVE:

to evaluate the association between XPD and XRCC3 polymorphisms and oral squamous cell carcinoma (OSCC).

DESIGN:

the sample consisted of 54 cases of OSCC and 40 cases of inflammatory fibrous hyperplasia (IFH). Genotypes were determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.

RESULTS:

XPD-Lys/Gln was more common in IFH (n=28; 70%) than in OSCC (n=24; 44.4%) (OR: 0.3; p<0.05). XPD-Gln was more frequent in high-grade lesions (0.48) than in low-grade lesions (0.21) (OR: 3.4; p<0.05). The Gln/Gln genotype was associated with III and IV clinical stages (OR: 0.07; p<0.05). XRCC3-Met was more frequent in OSCC (0.49) than in IFH (0.35) (OR: 2.6; p<0.05). The Met/Met genotype was associated with the presence of metastases (OR: 8.1; p<0.05) and with III and IV clinical stages (OR: 0.07; p<0.05).

CONCLUSIONS:

in this sample, the frequency of XPD-Gln in IFH suggests that this variant may protect against OSCC. The presence of the XRCC3-Met allele seems to contribute to the development of OSCC, metastases and more advanced stages in these lesions.

• Authors: Joabe dos Santos Pereira, Fabrícia Lima Fontes, Silvia Regina Batistuzzo de Medeiros, Roseana de Almeida Freitas, Lélia Batista de Souza, Márcia Cristina da Costa Miguel
• Journal: Archives of oral biology (Arch Oral Biol) Vol. 64 Pg. 19-23 (Apr 2016) ISSN: 1879-1506 [Electronic] England
• PMID: 26742000 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier Ltd. All rights reserved.

Chemical References

• DNA, Neoplasm
• DNA-Binding Proteins
• X-ray repair cross complementing protein 3
• Xeroderma Pigmentosum Group D Protein
• ERCC2 protein, human

Topics

• Brazil
• Carcinoma, Squamous Cell (genetics, pathology)
• DNA Repair
• DNA, Neoplasm (genetics, isolation & purification)
• DNA-Binding Proteins (genetics)
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Genotype
• Head and Neck Neoplasms (genetics, pathology)
• Humans
• Male
• Mouth Neoplasms (genetics, pathology)
• Neoplasm Metastasis
• Pilot Projects
• Polymerase Chain Reaction (methods)
• Polymorphism, Genetic
• Polymorphism, Restriction Fragment Length
• Squamous Cell Carcinoma of Head and Neck
• Xeroderma Pigmentosum Group D Protein (genetics)