[Risk factors research for overt/non-overt die in abdominal aortic aneurysm patients undergoing endovascular aneurysm repair].

Abstract

OBJECTIVE:

To determine risk factors of overt/non-overt disseminated intravascular coagulation (DIC) in abdominal aortic aneurysm (AAA) patients undergoing endovascular aneurysm repair (EVAR).

METHODS:

In a retrospective study, 117 patients undergoing selective EVAR for AAA were investigated for overt/non-overt DIC from June 1st 2013 to December 31 2014. The following parameters were reviewed: D-dimer, Platelet count, fibrinogen and prothrombin time (PT) at before operation and 1, 2, and 7 days after operation. Non-overt DIC was defined as International Society on Thrombosis and Hemostasis (ISTH) score between 2 and 5, and overt DIC score ≥5. Factors associated with overt/non-overt DIC were identified by stepwise Logistic regression.

RESULTS:

Among 117 patients, who received EVAR for AAA, 3 patients (2. 5%) were diagnosed as overt DIC and 31 patients (26. 5%) were diagnosed as non-overt DIC. Univariate analysis showed significant risk factors for overt/non-overt DIC were aging, operating duration, blood loss, renal dysfunction and endoleak (P <0. 05). Stepwise Logistic regression showed that independent risk factors for overt/non-overt DIC were endoleak (B = 2. 118, SE = 0. 917, Wald =5. 335,P =0. 021), renal dysfunction (B = 2. 135, SE =0. 797, Wald = 7. 183, P = 0. 007) and operating duration (B = 0. 021, SE = 0. 006, Wald = 11. 126, P = 0. 001).

CONCLUSION:

Independent risk factors for non-overt DIC in patients who received EVAR for AAA are endoleak, renal dysfunction and operating duration.

• Authors: Rong Zeng, Wei Ye, Bao Liu, Leng Ni, Changwei Liu, Yongjun Li, Yuehong Zheng, Xiaojun Song, Jiang Shao, Yuexin Chen, Yu Chen, Zhili Liu
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 95 Issue 26 Pg. 2054-7 (Jul 14 2015) ISSN: 0376-2491 [Print] China
• PMID: 26710864 (Publication Type: Journal Article)

Chemical References

• Fibrin Fibrinogen Degradation Products
• fibrin fragment D
• Fibrinogen

Topics

• Aortic Aneurysm, Abdominal
• Blood Coagulation Tests
• Disseminated Intravascular Coagulation
• Endoleak
• Endovascular Procedures
• Fibrin Fibrinogen Degradation Products
• Fibrinogen
• Humans
• Logistic Models
• Platelet Count
• Retrospective Studies
• Risk Factors