Abstract | BACKGROUND: METHODS: We evaluated time-dependent associations of anemia and cross-sectional associations of red blood cell indices with neurocognitive impairment in a multicenter, HAART-era HIV cohort study (N = 1261), adjusting for potential confounders, including age, nadir CD4(+) T-cell count, zidovudine use, and comorbid conditions. Subjects underwent comprehensive neuropsychiatric and neuromedical assessments. RESULTS: HAND, defined according to standardized criteria, occurred in 595 subjects (47%) at entry. Mean corpuscular volume and mean corpuscular hemoglobin were positively associated with the global deficit score, a continuous measure of neurocognitive impairment (both P < .01), as well as with all HAND, milder forms of HAND, and HIV-associated dementia in multivariable analyses (all P < .05). Anemia independently predicted development of HAND during a median follow-up of 72 months (adjusted hazard ratio, 1.55; P < .01). CONCLUSIONS:
Anemia and red blood cell indices predict HAND in the HAART era and may contribute to risk assessment. Future studies should address whether treating anemia may help to prevent HAND or improve cognitive function in HIV-infected persons.
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Authors | Asha R Kallianpur, Quan Wang, Peilin Jia, Todd Hulgan, Zhongming Zhao, Scott L Letendre, Ronald J Ellis, Robert K Heaton, Donald R Franklin, Jill Barnholtz-Sloan, Ann C Collier, Christina M Marra, David B Clifford, Benjamin B Gelman, Justin C McArthur, Susan Morgello, David M Simpson, J A McCutchan, Igor Grant, CHARTER Study Group |
Journal | The Journal of infectious diseases
(J Infect Dis)
Vol. 213
Issue 7
Pg. 1065-73
(Apr 01 2016)
ISSN: 1537-6613 [Electronic] United States |
PMID | 26690344
(Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural)
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Copyright | © The Author 2015. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail [email protected]. |
Chemical References |
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Topics |
- AIDS Dementia Complex
(etiology)
- Adult
- Anemia
(blood, complications)
- Anti-HIV Agents
(therapeutic use)
- Antiretroviral Therapy, Highly Active
- Cohort Studies
- Cross-Sectional Studies
- Erythrocyte Count
- Erythrocyte Indices
- Female
- HIV Infections
(blood, complications)
- Humans
- Male
- Middle Aged
- Multivariate Analysis
- Odds Ratio
- Predictive Value of Tests
- Risk Factors
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