Abstract | OBJECTIVES: METHODS: Nine NP patients aged 64-84 years with ≥ 2 nocturnal voids received 2.5 µg of intranasal desmopressin for 4 weeks and were evaluated for its effectiveness. Prior to treatment, urinary AVP/Cr concentrations at first morning void and serum sodium and plasma natriuretic peptide (BNP) concentrations were measured, and all patients underwent 5% hypertonic saline infusion. RESULTS: Six responders to 2.5 µg desmopressin had average decreases in nocturnal frequency from 3.2 to 1.8 voids nightly and in nocturnal diuresis by 40%, without clinically significant adverse events. Non-responders remained unaffected even with dose escalation to 5.0 µg desmopressin. For responders, urinary AVP/Cr concentrations were less than 14 pg/mg · Cr, which is lower than in non-responders. Within a physiological range of plasma osmolality, plasma AVP release in response to 5% hypertonic saline infusion was less in responders than in non-responders. Blood pressure measurements and BNP concentrations were unchanged. CONCLUSIONS: Urinary AVP/Cr at first morning void may have potential clinical value as a predictor for responsiveness to low-dose desmopressin in nocturia with NP.
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Authors | Osamu Natsume, Masaya Hashimura, Chie Matsushita, Kazumasa Torimoto, Akihide Hirayama, Kiyohide Fujimoto |
Journal | Lower urinary tract symptoms
(Low Urin Tract Symptoms)
Vol. 6
Issue 2
Pg. 107-12
(May 2014)
ISSN: 1757-5672 [Electronic] Australia |
PMID | 26663550
(Publication Type: Journal Article)
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Copyright | © 2013 Wiley Publishing Asia Pty Ltd. |