Association between IL6 polymorphism and risk of cerebral infarction.

Abstract

We conducted a case-control study to investigate the influence of IL6 -174G/C (rs1800795) and -572C/G (rs1800796) genetic variants on the development of cerebral thrombosis in a Chinese population. This study included 305 cerebral infarction patients and 326 control subjects enrolled between May 2012 and May 2014. The genotyping of IL6 -174G/C (rs1800795) and -572C/G (rs1800796) polymorphisms was performed using polymerase chain reaction combined with restriction fragment length polymorphism analysis. By using logistic regression, we found that when compared with the wild-type genotype, CC and GC+CC IL6 -174G/C (rs1800795) genotypes were associated with an increased risk of cerebral infarction. Odds ratios (and 95% confidence intervals) were calculated to be 3.10 (1.57-6.41) and 1.63 (1.14-2.33) for the CC and GC+CC genotypes, respectively. In conclusion, our study suggests that the CC genotype and C allele of the IL6 -174G/C (rs1800795) polymorphism are associated with an increased risk of cerebral infarction.

• Authors: Y H Han
• Journal: Genetics and molecular research : GMR (Genet Mol Res) Vol. 14 Issue 4 Pg. 16438-43 (Dec 09 2015) ISSN: 1676-5680 [Electronic] Brazil
• PMID: 26662441 (Publication Type: Journal Article)

Chemical References

• Interleukin-6

Topics

• Adult
• Aged
• Alleles
• Case-Control Studies
• Cerebral Infarction (epidemiology, genetics)
• Comorbidity
• Female
• Gene Frequency
• Genetic Association Studies
• Genetic Predisposition to Disease
• Genotype
• Humans
• Interleukin-6 (genetics)
• Male
• Middle Aged
• Odds Ratio
• Polymorphism, Single Nucleotide
• Risk