Leydig cell tumour and giant adrenal myelolipoma associated with adrenogenital syndrome: a case report with a review of the literature.

Abstract

CONTEXT:

Male patients with congenital adrenal hyperplasia (CAH) may develop bilateral testicular adrenal rest tumours (TARTs). These tumours, in most cases, regress with glucocorticoid therapy and their histological differentiation from Leydig-cell tumors is quite difficult.

OBJECTIVE:

The aim of this study was to differentiate the histological and clinical features of the TARTs from those of the Leydig-cell tumours.

METHODS:

The authors report a case of bilateral Leydig-cell tumour associated with giant bilateral adrenal myelolipoma in a male with adrenogenital syndrome who was submitted to a bilateral orchiectomy.

RESULTS:

Testicular neoplasia continue to grow despite adequate hormonal treatment and a bilateral orchiectomy was performed. The histopathological examination of the specimen ultimately confirmed the diagnosis of bilateral Leydig-cell tumour.

CONCLUSIONS:

This case shows the importance of all the relevant examinations, blood chemistry analysis, and instrumental tests in the differential diagnosis of TARTs and other testicular tumours.

• Authors: Vincenzo M Altieri, Barbara Altieri, Roberto Castellucci, Stefano Alba, Francesco Bottone, Eugenia Fragalà, Vincenzo Mirone, Francesco Greco
• Journal: Urologia (Urologia) 2016 Jan-Mar Vol. 83 Issue 1 Pg. 43-8 ISSN: 1724-6075 [Electronic] United States
• PMID: 26660266 (Publication Type: Case Reports, Journal Article, Review)

Topics

• Adrenal Gland Neoplasms (complications, pathology, surgery)
• Adrenogenital Syndrome (complications, pathology, surgery)
• Adult
• Humans
• Leydig Cell Tumor (complications, pathology, surgery)
• Male
• Myelolipoma (complications, pathology, surgery)
• Neoplasms, Multiple Primary (complications, pathology, surgery)
• Testicular Neoplasms (pathology, surgery)