Damaged goods?: an empirical cohort study of blood specimens collected 12 to 23 hours after birth in newborn screening in California.

Abstract

PURPOSE:

The current Clinical and Laboratory Standards Institute standard recommends blood collection from 24 to 48 hours after birth for newborn genetic disorder screening. We used California population-level data to determine whether early specimens (collected from 12 to 23 hours) would also be considered satisfactory based on screening performance.

METHODS:

Screening data from California Genetic Disease Screening Program were analyzed for false-negative and false-positive rates in four disease categories: metabolic disorders detectable by tandem mass spectrometry (MS/MS); congenital adrenal hyperplasia (CAH); congenital hypothyroidism (CH); and initial immune reactive trypsinogen (IRT) for cystic fibrosis (CF). We compared the rates between the early-collection group (12 to 23 hours) and the standard-collection group (24 to 48 hours).

RESULTS:

No significant difference of false-negative rate was detected between the two collection-timing groups. Early specimens had a significantly higher false-positive rate for CH (0.10 vs. 0.01%) and IRT (1.85 vs. 1.54%) but a lower false-positive rate for MSMS metabolic disorders (0.11 vs. 0.18%) and CAH (0.10 vs. 0.14%).

CONCLUSION:

Newborn specimens collected after 12 hours provided satisfactory screening performance. A policy allowing earlier collection could improve timeliness of reporting screening results.

• Authors: Hao Tang, Lisa Feuchtbaum, Partha Neogi, Thomson Ho, Leslie Gaffney, Robert J Currier
• Journal: Genetics in medicine : official journal of the American College of Medical Genetics (Genet Med) Vol. 18 Issue 3 Pg. 259-64 (Mar 2016) ISSN: 1530-0366 [Electronic] United States
• PMID: 26656653 (Publication Type: Comparative Study, Journal Article)

Topics

• Adrenal Hyperplasia, Congenital (diagnosis)
• Blood Specimen Collection (standards)
• California
• Cohort Studies
• Congenital Hypothyroidism (diagnosis)
• Cystic Fibrosis (diagnosis)
• False Positive Reactions
• Genetic Testing (standards)
• Humans
• Infant, Newborn
• Male
• Metabolic Diseases (diagnosis)
• Neonatal Screening (methods, standards)
• Time Factors