Abstract | OBJECTIVE: DESIGN: Single center prospective randomized study. SETTING: University Hospital Regensburg, Germany. PATIENTS: INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Three different extracorporeal membrane oxygenation systems: the Cardiohelp system (Maquet Cardiopulmonary AG), the Dideco ECC.O5 (Sorin Group), and the Deltastream system with Hilite 7000 LT + DP3 pumphead (Medos Medizintechnik AG) were compared. Therefore hemostasis, anticoagulation, hemolysis, and inflammatory parameters were monitored. Of the 54 patients included in the study, 18 patients each were randomly assigned to the three different extracorporeal membrane oxygenation systems. Exclusion criteria were acute renal failure, trauma, and surgery within 2 days. The median time on veno-venous extracorporeal membrane oxygenation support was 13.5 days (4-70 d). Median platelet count had dropped from 220.5 G/L before extracorporeal membrane oxygenation therapy to a minimum of 133 G/L by the last day of extracorporeal membrane oxygenation support. During the first 5 days of extracorporeal membrane oxygenation therapy, prothrombin fragment 1.2 (F1.2) (1.36-2.4 µM), thrombin-antithrombin complex (14.5-50 µg/L), and D-dimers (6.00-27.0 mg/L) increased, whereas fibrinogen values dropped from 5.8 to 4.1 g/L. The three different extracorporeal membrane oxygenation systems did not show any differences with regard to hemostasis, anticoagulation, hemolysis, and inflammatory parameters within the first 5 days of extracorporeal membrane oxygenation therapy. CONCLUSIONS:
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Authors | Maximilian V Malfertheiner, Alois Philipp, Matthias Lubnow, Florian Zeman, Tone Bull Enger, Thomas Bein, Dirk Lunz, Christof Schmid, Thomas Müller, Karla Lehle |
Journal | Critical care medicine
(Crit Care Med)
Vol. 44
Issue 4
Pg. 747-54
(Apr 2016)
ISSN: 1530-0293 [Electronic] United States |
PMID | 26646464
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticoagulants
- Peptide Fragments
- prothrombin fragment 1.2
- Prothrombin
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Topics |
- Adult
- Aged
- Anticoagulants
(therapeutic use)
- Blood Coagulation
(physiology)
- Extracorporeal Membrane Oxygenation
(instrumentation)
- Female
- Germany
- Hemolysis
(physiology)
- Hemostasis
(physiology)
- Humans
- Male
- Middle Aged
- Peptide Fragments
- Prospective Studies
- Prothrombin
- Respiratory Distress Syndrome
(physiopathology, therapy)
- Respiratory Insufficiency
(therapy)
- Thrombosis
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