Clinical assessment of coded Unani formulation D-worm and mebandazole for the treatment of hook worm, roundworm and whip worm.

Abstract

A case control, multicenter, prospective randomized two arm parallel group clinical trials was conducted on 190 patients. The main objective of this study is to provide comparative efficacy results of both trialed medicines. The comparison was done in between herbal medicine D-Worm and Mebandazole allopathic drug for the treatment of helminthiasis. All the rules of GCP (Good Clinical Practices) were followed including clinical history, clinical presentation, examination findings and stool tests. Stool D/R and Parasite antigen tests were performed before and after treatment. The comparison of symptoms were also done including the improvement in abdominal pain, worms in stool, anal itching, nausea and vomiting, loss of appetite, and fatigue etc. The data on clinical proforma was gathered and subjected to statistical analysis. Parasite specific antigen test and stool D/R is considered as gold standard test for the diagnosis and confirmation of helminthes infection. Different parameter i.e. age, sex, and other clinical sign and symptoms were studied and compared between two treatment groups (Control and Test groups) at baseline and end of therapeutic application. Consent of patient was taken at first before the start of examination. Majority of the patients (90%) included in this study group get cured after herbal treatment. The statistical analysis used for the assessment of the effect of the treatment also showed significant improvement after treatment.

• Authors: Khalil Ahmad, Khan Usmanghani, Naveed Akhtar, Halima Nazar
• Journal: Pakistan journal of pharmaceutical sciences (Pak J Pharm Sci) Vol. 28 Issue 6 Pg. 2115-8 (Nov 2015) ISSN: 1011-601X [Print] Pakistan
• PMID: 26639505 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Antigens, Helminth
• Antinematodal Agents
• D-Worm
• Plant Extracts
• Mebendazole

Topics

• Adolescent
• Adult
• Ancylostomatoidea (drug effects, immunology, pathogenicity)
• Animals
• Antigens, Helminth (immunology)
• Antinematodal Agents (adverse effects, therapeutic use)
• Child
• Feces (parasitology)
• Female
• Hookworm Infections (diagnosis, drug therapy, parasitology)
• Humans
• Intention to Treat Analysis
• Male
• Mebendazole (adverse effects, therapeutic use)
• Medicine, Unani
• Pakistan
• Phytotherapy
• Plant Extracts (adverse effects, therapeutic use)
• Plants, Medicinal
• Prospective Studies
• Time Factors
• Treatment Outcome
• Young Adult