The effect of hydroxyethylrutoside and its combination with acetylsalicylic acid in patients with obliterative atherosclerosis.

Abstract

The effect of 7-mono-hydroxyethylrutoside and its combination with acetylsalicylic acid was evaluated in a controlled clinical trial, performed in 105 patients with obliterative atherosclerosis of the lower limbs, and using non-invasive measurement of peripheral haemodynamic parameters--blood flow during reactive hyperaemia and ankle systolic blood pressure. Patients, randomized into three groups, received either placebo or 7-mono-hydroxyethylrutoside alone or in combination with acetylsalicylic acid for 12 months. The placebo group showed a decrease in maximum calf blood flow and a decrease in ankle systolic pressure. Administration of 7-mono-hydroxyethylrutoside did not lead to any significant changes in systolic pressure but there was a decrease in the maximum calf blood flow. There were no statistically significant changes in patients receiving the 7-mono-hydroxyethylrutoside and acetylsalicylic acid combination who, by contrast, showed a tendency to increased values of the parameters measured.

• Authors: K Roztocil, I Oliva, I Prerovský, J Linhart
• Journal: Cor et vasa (Cor Vasa) Vol. 31 Issue 2 Pg. 128-33 ( 1989) ISSN: 0010-8650 [Print] Czech Republic
• PMID: 2663343 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Analgesics
• Anticoagulants
• Hydroxyethylrutoside
• Rutin
• aloxiprin
• troxevasin
• Aspirin

Topics

• Adult
• Analgesics (administration & dosage)
• Anticoagulants (administration & dosage)
• Arteriosclerosis Obliterans (drug therapy)
• Aspirin (administration & dosage, analogs & derivatives)
• Clinical Trials as Topic
• Drug Therapy, Combination
• Female
• Hemodynamics (drug effects)
• Humans
• Hydroxyethylrutoside (administration & dosage, analogs & derivatives)
• Ischemia (drug therapy)
• Leg (blood supply)
• Male
• Middle Aged
• Plethysmography
• Rutin (analogs & derivatives)