Abstract | UNLABELLED: Background. Starch is one of the most potential natural polymers used for various bio applications. Literature reports a num- ber of modification strategies such as physical, chemical, enzymatic and genetic to enhance the positive attributes and iron out the undesired features of neat starch. OBJECTIVES: MATERIAL AND METHODS: The CPS carrier was synthesized using a natural crosslinker, malic acid. The drug delivery system was formulated, followed by the in situ loading of calcium carbonate during the preparation of the CPS. The developed system was characterized with respect to FTIR, DSC, SEM, moisture content, zeta potential, encapsulation efficiency, phosphate binding efficiency and dissolution studies. RESULTS: The developed formulation was observed to deliver calcium carbonate in an enterically controlled manner. The binding of calcium to phosphate was established to be pH dependent and efficient at pH 7. The moisture content of CPS was in the range of 0.2-0.8%. The zeta potential of the colloidal system was noted to be sufficiently high, indicating the stability. The encapsulation efficiency of CPS particles for calcium was found to be 88-96%. CONCLUSIONS:
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Authors | Tarique Ali Meer, Kailas Moravkar, Jaywant Pawar, Purnima Amin |
Journal | Polimery w medycynie
(Polim Med)
2015 Jan-Jun
Vol. 45
Issue 1
Pg. 11-9
ISSN: 0370-0747 [Print] Poland |
PMID | 26630724
(Publication Type: Journal Article)
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Chemical References |
- Cross-Linking Reagents
- Delayed-Action Preparations
- Drug Carriers
- Malates
- Phosphates
- Tablets, Enteric-Coated
- malic acid
- Starch
- Calcium Carbonate
- Calcium
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Topics |
- Calcium
(chemistry)
- Calcium Carbonate
(administration & dosage, chemistry)
- Chemistry, Pharmaceutical
- Cross-Linking Reagents
(chemical synthesis, chemistry)
- Delayed-Action Preparations
- Drug Carriers
(chemical synthesis, chemistry)
- Drug Delivery Systems
(methods)
- Hydrogen-Ion Concentration
- Malates
(chemistry)
- Particle Size
- Phosphates
(chemistry)
- Porosity
- Starch
(chemical synthesis, chemistry)
- Tablets, Enteric-Coated
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