Prevalence of Classic and Non-Classic Antiphospholipid Antibodies in Multiple Sclerosis.

Abstract

BACKGROUND:

The association between antiphospholipid antibodies (aPL) and multiple sclerosis (MS) has been suggested previously, but prior studies provided contradicting findings.

OBJECTIVES:

To characterize the expression profile of eight classic and non-classic aPL in patients diagnosed with MS.

METHODS:

Using the BioPlex 2200 immunoassay, we measured the levels of serum immunoglobulin (Ig)M and IgG isotypes of three classic aPL and five non-classic aPL in 98 subjects with MS and 237 healthy controls.

RESULTS:

Three non-classic aPL were significantly more prevalent among MS patients in comparison to the control group. These antibodies included IgM and IgG against phosphatidylserine-β2GPI (PS-B2), IgG prothrombin complex (PT-PT) and IgM prothrombin (PT). The positive results according to Bonferroni correction are PS-B2 IgG and PT-PT IgG. The remaining aPL profiles did not differ significantly between the two groups.

CONCLUSIONS:

An association between certain non-classic aPL and MS has been established. The specific role of these autoantibodies in the pathogenesis of the condition remains uncertain.

• Authors: Dana Ben-Ami Shor, Guy A Weiss, Ori Barzilai, Maya Ram, Juan-Manuel Anaya, Yehuda Shoenfeld, Yaniv Sherer
• Journal: The Israel Medical Association journal : IMAJ (Isr Med Assoc J) Vol. 17 Issue 9 Pg. 559-62 (Sep 2015) ISSN: 1565-1088 [Print] Israel
• PMID: 26625546 (Publication Type: Journal Article)

Chemical References

• Antibodies, Antiphospholipid
• Immunoglobulin G
• Immunoglobulin M

Topics

• Adult
• Antibodies, Antiphospholipid (blood)
• Case-Control Studies
• Cross-Sectional Studies
• Female
• Humans
• Immunoglobulin G (blood)
• Immunoglobulin M (blood)
• Male
• Middle Aged
• Multiple Sclerosis (blood, immunology)
• Prevalence