Protective Effect of Ocimum basilicum Essential Oil Against Acetic Acid-Induced Colitis in Rats.

Abstract

Ocimum basilicum L has been traditionally used for the treatment of inflammatory bowel disease in Iran. This study investigates the ameliorative effect of Ocimum basilicum essential oil on an acetic acid-induced colitis model in rats. Ocimum basilicum essential oil with 2 doses (200 and 400 μL/kg) significantly ameliorated wet weight/length ratio of colonic tissue compared to the control group. Higher doses of essential oil (200 and 400 μL/kg) significantly reduced ulcer severity, ulcer area, and ulcer index. On the other hand, histological examination revealed the diminution of total colitis index as a marker for inflammatory cell infiltration in the colonic segments of rats treated with Ocimum basilicum essential oil (200 and 400 μL/kg). The increased level of myeloperoxidase was significantly decreased after the treatment with the essential oil (200 and 400 μL/kg). These results suggest that Ocimum basilicum exhibits protective effect against acetic acid-induced colitis.

• Authors: Amir Rashidian, Parnia Roohi, Saeed Mehrzadi, Ali Reza Ghannadi, Mohsen Minaiyan
• Journal: Journal of evidence-based complementary & alternative medicine (J Evid Based Complementary Altern Med) Vol. 21 Issue 4 Pg. NP36-42 (Oct 2016) ISSN: 2156-5899 [Electronic] United States
• PMID: 26620574 (Publication Type: Journal Article)
• Copyright: © The Author(s) 2015.

Chemical References

• Oils, Volatile
• Protective Agents
• Peroxidase
• Acetic Acid

Topics

• Acetic Acid (adverse effects)
• Animals
• Colitis (chemically induced, drug therapy, pathology)
• Colon (drug effects, enzymology, pathology)
• Disease Models, Animal
• Iran
• Male
• Ocimum basilicum (chemistry)
• Oils, Volatile (pharmacology, therapeutic use)
• Peroxidase
• Protective Agents (pharmacology, therapeutic use)
• Rats
• Rats, Wistar