An evaluation of entecavir for the treatment of chronic hepatitis B infection in adults.

Abstract

Entecavir is a nucleoside analogue of 2'-deoxyguanosine whose intracellular triphosphate form inhibits replication of the hepatitis B virus. Entecavir is recommended as a first-line monotherapy option for nucleos(t)ide-naïve patients with HBeAg-positive or -negative chronic hepatitis B infection. Entecavir has a three-step mechanism of action: It maintains viral suppression with a greater than 90% chance of undetectable hepatitis B virus DNA during continuous therapy, improves liver histology, and reduces the risk of liver failure or hepatocellular carcinoma development. The safety profile of long-term entecavir therapy is favorable; however, its optimal treatment duration is unknown. Entecavir monotherapy is not a rescue option for patients with lamivudine/adefovir resistance or baseline lamivudine-resistant mutants; rather, combination treatment is recommended for patients with lamivudine/adefovir resistance.

• Authors: Hye Won Lee, Jun Yong Park, Sang Hoon Ahn
• Journal: Expert review of gastroenterology & hepatology (Expert Rev Gastroenterol Hepatol) Vol. 10 Issue 2 Pg. 177-86 ( 2016) ISSN: 1747-4132 [Electronic] England
• PMID: 26610256 (Publication Type: Journal Article, Review)

Chemical References

• Antiviral Agents
• DNA, Viral
• entecavir
• Guanine

Topics

• Animals
• Antiviral Agents (administration & dosage, adverse effects, therapeutic use)
• Carcinoma, Hepatocellular (prevention & control, virology)
• DNA, Viral (blood, genetics)
• Drug Administration Schedule
• Drug Resistance, Multiple, Viral
• Drug Substitution
• Guanine (administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
• Hepatitis B virus (drug effects, genetics, growth & development)
• Hepatitis B, Chronic (complications, diagnosis, drug therapy)
• Humans
• Liver Cirrhosis (drug therapy, virology)
• Liver Neoplasms (prevention & control, virology)
• Treatment Outcome
• Viral Load
• Virus Replication (drug effects)