[Pathological and clinical correlations in renal AA amyloidosis: A Moroccan series of 30 cases].

Abstract

OBJECTIVE:

Study of histological and clinical correlations of 30 cases of renal amyloidosis AA diagnosed between November 2010 and December 2012.

RESULTS:

The main causes associated with amyloidosis AA were represented by chronic infectious diseases (60%). Nephrotic syndrome and renal failure were observed in 94% and 73% respectively. The distribution of amyloid deposits: 90% of patients had a glomerular form and 10% had a vascular form. Inflammatory reaction associated with AA renal amyloidosis was present in 50% of cases. This inflammation was observed near amyloid deposits associated with a deposition of immunoglobulin chains and/or complement factors.

CONCLUSION:

Our study confirms the predominance of AA amyloidosis complicating chronic infectious diseases, especially tuberculosis. Our data point out a relationship between the morphology of renal AA amyloidosis, its clinical presentation and prognosis.

• Authors: Asmae Bziz, Lamia Rouas, Najat Lamalmi, Abderrahmane Malihy, Nadia Cherradi, Naima Ouzeddoun, Rabia Bayahia, Kaoutar Flayou, Sanae Chala, Aziz Bouclouze, Ali Benomar, Redouan Abouqal, Zaitouna Alhamany
• Journal: Nephrologie & therapeutique (Nephrol Ther) Vol. 11 Issue 7 Pg. 543-50 (Dec 2015) ISSN: 1872-9177 [Electronic] France
• Vernacular Title: Amyloses rénales AA : corrélations anatomocliniques dans une série marocaine de 30 cas.
• PMID: 26608566 (Publication Type: Journal Article)
• Copyright: Copyright © 2015 Association Société de néphrologie. Published by Elsevier SAS. All rights reserved.

Topics

• Adult
• Amyloidosis (pathology)
• Chronic Disease
• Female
• Humans
• Inflammation
• Kidney (pathology)
• Kidney Diseases (pathology)
• Male
• Middle Aged
• Morocco
• Plaque, Amyloid