Abstract | OBJECTIVES: METHODS: We enrolled 101 pSS patients with normal liver function and structures, and without significant liver diseases or other conditions affecting liver fibrosis. The European league against rheumatism (EULAR) SS patients reported index (ESSPRI) and the EULAR SS disease activity index (ESSDAI) were analyzed. Liver stiffness (LS) was measured using transient elastography and 7.4 kPa was determined as the cutoff value for significant liver fibrosis. RESULTS: The median age of patients (91women) was 53 years and the median LS value was 4.7 kPa. The median ESSPRI and ESSDAI showed no correlation with LS values. Twelve patients (11.9%) had significant liver fibrosis. In multivariate logistic regression, white blood cells count ≤4000.0/mm(3) (Odds ratio [OR] 9.821), serum albumin ≤3.8 mg/dL (OR 16.770) and aspartate aminotransferase (AST) ≥ 27.0 IU/L (OR 20.858) independently predicted silent but substantial liver fibrosis in pSS patients. CONCLUSIONS:
|
Authors | Sang-Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Jungsik Song, Yong-Beom Park, Soo-Kon Lee, Kwang-Hyub Han, Seung Up Kim |
Journal | Modern rheumatology
(Mod Rheumatol)
Vol. 26
Issue 4
Pg. 576-82
(Jul 2016)
ISSN: 1439-7609 [Electronic] England |
PMID | 26587876
(Publication Type: Journal Article)
|
Topics |
- Adult
- Asymptomatic Diseases
(epidemiology)
- Elasticity Imaging Techniques
(methods)
- Female
- Humans
- Liver
(diagnostic imaging)
- Liver Cirrhosis
(diagnosis, epidemiology, etiology, physiopathology)
- Liver Function Tests
(methods)
- Male
- Middle Aged
- Patient Acuity
- Predictive Value of Tests
- Prevalence
- Republic of Korea
(epidemiology)
- Sjogren's Syndrome
(complications, diagnosis)
- Ultrasonography
(methods)
|