TSH receptor antibody titers measured with a third-generation assay did not reflect the activity of Graves' ophthalmopathy in untreated Japanese Graves' disease patients.

Abstract	TSH receptor antibody (TRAb) titer has been reported to be correlated with Graves' ophthalmopathy (GO). However, the correlation between GO activity and TRAb titer assessed with a third-generation assay has not been reported. We enrolled 238 untreated Graves' disease patients who came to the outpatient clinic of Ito Hospital and 28 patients who were euthyroid. All of the patients were assessed for GO by an ophthalmologist within 3 months of their initial visit to Ito Hospital. Clinical activity score (CAS), short inversion time inversion recovery (STIR), and sum of the maximum external orbital muscle areas (SEOMA) on a frontal sectional magnetic resonance imaging (MRI). The TRAb titer was significantly higher in patients with inactive ophthalmopathy (the inactive-GO group) than in patients with active ophthalmopathy (the active-GO group) (17.7 ± 13.5 IU/L vs. 13.0 ± 13.1 IU/L, p=0.0082). The SEOMA values were not correlated with TRAb titer. The prevalence of active-GO was higher in euthyroid patients than in hyperthyroid patients although the difference was not significant. In conclusion, TRAb titer measured with a third-generation assay dose not correlate with GO activity based on MRI findings in untreated Graves' disease patients, and the prevalence of active-GO is higher in euthyroid patients with lower TRAb titers than in hyperthyroid patients.
Authors	Koji Mukasa, Jaeduk Yoshimura Noh, Ai Kouzaki, Hidemi Ohye, Yo Kunii, Natsuko Watanabe, Ai Yoshihara, Masako Matsumoto, Miho Suzuki, Koichi Ito
Journal	Endocrine journal (Endocr J) Vol. 63 Issue 2 Pg. 151-7 ( 2016) ISSN: 1348-4540 [Electronic] Japan
PMID	26581710 (Publication Type: Evaluation Study, Journal Article)
Chemical References	Immunoglobulins, Thyroid-Stimulating thyrotropin-binding inhibitory immunoglobulin
Topics	Adolescent Adult Aged Child Disease Progression Female Graves Disease (blood, complications, pathology) Graves Ophthalmopathy (blood, diagnosis) Hematologic Tests (methods) Humans Immunoglobulins, Thyroid-Stimulating (analysis, blood) Japan Magnetic Resonance Imaging Male Middle Aged Prognosis Young Adult

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