Comparison of intravascular ultrasound guided versus angiography guided drug eluting stent implantation: a systematic review and meta-analysis.

Abstract

BACKGROUND:

Intravascular ultrasound (IVUS) can be a useful tool during drug-eluting stents (DES) implantation as it allows accurate assessment of lesion severity and optimal treatment planning. However, numerous reports have shown that IVUS guided percutaneous coronary intervention is not associated with improved clinical outcomes, especially in non-complex patients and lesions.

METHODS:

We searched the literature in Medline, the Cochrane Library, and other internet sources to identify studies that compare clinical outcomes between IVUS-guided and angiography-guided DES implantation. Random-effects model was used to assess treatment effect.

RESULTS:

Twenty eligible studies with a total of 29,068 patients were included in this meta-analysis. The use of IVUS was associated with significant reductions in major adverse cardiovascular events (MACE, odds ratios [OR] 0.77, 95 % confidence intervals [CI] 0.71-0.83, P < 0.001), death (OR 0.62, 95 % CI 0.54-0.71, p < 0.001), and stent thrombosis (OR 0.59, 95 % CI: 0.47-0.73, P < 0.001). The benefit was also seen in the repeated analysis of matched and randomized studies. In stratified analysis, IVUS guidance appeared to be beneficial not only in patients with complex lesions or acute coronary syndromes (ACS) but also patients with mixed lesions or presentations (MACE: OR 0.69, 95 % CI: 0.60-0.79, p < 0.001, OR 0.81, 95 % CI 0.74-0.90, p < 0.001, respectively). By employing meta-regression analysis, the benefit of IVUS is significantly pronounced in patients with complex lesions or ACS with respect to death (p = 0.048).

CONCLUSIONS:

IVUS guidance was associated with improved clinical outcomes, especially in patients with complex lesions admitted with ACS. Large, randomized clinical trials are warranted to identify populations and lesion characteristics where IVUS guidance would be associated with better outcomes.

• Authors: Yao-Jun Zhang, Si Pang, Xiao-Yun Chen, Christos V Bourantas, Dao-Rong Pan, Sheng-Jie Dong, Wen Wu, Xiao-Min Ren, Hao Zhu, Shun-Yi Shi, Javaid Iqbal, Bill D Gogas, Bo Xu, Shao-Liang Chen
• Journal: BMC cardiovascular disorders (BMC Cardiovasc Disord) Vol. 15 Pg. 153 (Nov 17 2015) ISSN: 1471-2261 [Electronic] England
• PMID: 26577590 (Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)

Topics

• Aged
• Coronary Angiography
• Coronary Artery Disease (diagnostic imaging, mortality, therapy)
• Coronary Vessels (diagnostic imaging)
• Drug-Eluting Stents
• Female
• Humans
• Male
• Middle Aged
• Odds Ratio
• Percutaneous Coronary Intervention (adverse effects, instrumentation, mortality)
• Predictive Value of Tests
• Propensity Score
• Risk Assessment
• Risk Factors
• Severity of Illness Index
• Treatment Outcome
• Ultrasonography, Interventional