Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: Germline STAT3 gain-of-function mutations have recently been identified in patients with an early-onset autoimmunity/lymphoproliferative syndrome. STAT3 plays a previously unrecognized role in several facets of the pathogenesis of allergy. Loss-of-function STAT3 mutations revealed critical roles for STAT3 in the development and function of several lymphocyte populations and in their role in host defense. SUMMARY: The discovery of new gain-of-function mutations in STAT3, as well as new studies among patients with loss-of-function mutations, expand the understanding of the pathophysiology of STAT3 function and its importance in regulating the immune system. These findings contribute to elucidating STAT3 biology and clinical symptoms in patients with the different disease phenotypes.
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Authors | Lisa R Forbes, Josh Milner, Elie Haddad |
Journal | Current opinion in hematology
(Curr Opin Hematol)
Vol. 23
Issue 1
Pg. 23-7
(Jan 2016)
ISSN: 1531-7048 [Electronic] United States |
PMID | 26574998
(Publication Type: Journal Article, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Antibodies
- Interleukin-17
- STAT3 Transcription Factor
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Topics |
- Animals
- Antibodies
(immunology)
- Autoimmunity
- B-Lymphocyte Subsets
(immunology, metabolism)
- Cytotoxicity, Immunologic
- Humans
- Hypersensitivity
(genetics, immunology, metabolism)
- Immunologic Memory
- Infections
(genetics, immunology, metabolism, microbiology, virology)
- Interleukin-17
(biosynthesis)
- Killer Cells, Natural
(immunology, metabolism)
- Lymphoproliferative Disorders
(genetics, immunology, metabolism)
- Mutation
- STAT3 Transcription Factor
(genetics, metabolism)
- Signal Transduction
- T-Lymphocyte Subsets
(immunology, metabolism)
- Th17 Cells
(immunology, metabolism)
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